Effects of dietary supplementation with bioactive peptides derived from rapeseed protein on the growth performance, serum biochemistry and faecal micro-organism composition of weaned piglets.

Publisher: Blackwell Science Country of Publication: Germany NLM ID: 101126979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-0396 (Electronic) Linking ISSN: 09312439 NLM ISO Abbreviation: J Anim Physiol Anim Nutr (Berl) Subsets: MEDLINE

Original Publication: [Berlin] : Blackwell Science, c2001-

Brassica napus*; Animals ; Swine ; Dietary Supplements ; Diet/veterinary ; Peptides ; Diarrhea/prevention & control ; Diarrhea/veterinary

The present study investigated the effects of supplementing bioactive peptides derived from rapeseed protein (rapeseed peptide, Rsp) on the growth performance, serum biochemistry and faecal micro-organism composition of weaned piglets. Sixty Duroc × Landrace × Yorkshire weaned piglets of similar weights were randomly divided into three groups. The control group (NC) was fed a basal diet, and the two treatment groups, Rsp-1 and Rsp-2, were fed a basal diet supplemented with 1% or 2% Rsp, respectively, for 28 days. Each treatment consisted of five replicates with four piglets per replicate. The results showed that Rsp treatment significantly improved the average daily gain and had a better feed-to-gain ratio (p < 0.05). The diarrhoea incidence and indices of Rsp-1 and Rsp-2 groups were significantly lower than the NC group (p < 0.05), and the effect of Rsp-2 on reducing the incidence of diarrhoea was significantly higher than that of Rsp-1 (p < 0.05). The serum albumin, serum immunoglobulin A and catalase levels of the Rsp-1 and Rsp-2 groups were significantly better than the NC group (p < 0.05). Additionally, Rsp treatment significantly gained the relative abundance of faecal Lactobacillaceae and decreased the relative abundance of faecal Eubacterium_coprostanoligenes_group, Treponema and Coprococcus (p < 0.05). In summary, Rsp supplementation improved the growth performance, ameliorated the diarrhoea, enhanced the immune and antioxidant functions and changed the composition of faecal micro-organisms in piglets. These findings indicate that Rsp positively affected the health of weaned piglets.
(© 2022 Wiley-VCH GmbH.)

Abdollahi, M. R., Zaefarian, F., Gu, Y., Xiao, W., Jia, J., & Ravindran, V. (2017). Influence of soybean bioactive peptides on growth performance, nutrient utilisation, digestive tract development and intestinal histology in broilers. Journal of Applied Animal Nutrition, 5, e7. https://doi.org/10.1017/JAN.2017.6.
Alashi, A. M., Blanchard, C. L., Mailer, R. J., & Agboola, S. O. (2013). Technological and bioactive functionalities of Canola meal proteins and hydrolysates. Food Reviews International, 29(3), 231-260. https://doi.org/10.1080/87559129.2013.790046.
Aly, S., Ouattara, C., Bassole, I., & Alfred, T. S. (2006). Bacteriocins and lactic acid bacteria-a minireview. African Journal of Biotechnology, 5(9), 678-683. https://doi.org/10.5897/AJB05.388.
Chatterjee, C., Gleddie, S., & Xiao, C.-W. (2018). Soybean bioactive peptides and their functional properties. Nutrients, 10(9), 1211. https://doi.org/10.3390/nu10091211.
Chen, L., Xu, Y., Chen, X., Fang, C., Zhao, L., & Chen, F. (2017). The maturing development of gut microbiota in commercial piglets during the weaning transition. Frontiers in Microbiology, 8, 1688. https://doi.org/10.3389/fmicb.2017.01688.
Chiesa, S. T., & Charakida, M. (2019). High-density lipoprotein function and dysfunction in health and disease. Cardiovascular Drugs and Therapy, 33(2), 207-219. https://doi.org/10.1007/s10557-018-06846-w.
Chu, Y., & Lin, Y. (2012). Nutrition characteristics of small-peptide and its application in weaned piglets production. China Feed, 12, 18-20. https://en.cnki.com.cn/Article_en/CJFDTotal-SLGZ201217006.htm.
Daniel, H. (2004). Molecular and integrative physiology of intestinal peptide transport. Annual Review of Physiology, 66, 361-384. https://doi.org/10.1146/annurev.physiol.66.032102.144149.
Feng, X., Wei, X., & Yang, B. (2013). Effects of soybean protein active peptide on growth performance of weaned piglets. China Feed, 21, 25-26. https://en.cnki.com.cn/Article_en/CJFDTotal-SLGZ201321008.htm.
Frese, S. A., Parker, K., Calvert, C. C., & Mills, D. A. (2015). Diet shapes the gut microbiome of pigs during nursing and weaning. Microbiome, 3, 28. https://doi.org/10.1186/s40168-015-0091-8.
Gilbert, E. R., Wong, E. A., & Webb, K. E., Jr. (2008). Board-invited review: Peptide absorption and utilization: Implications for animal nutrition and health. Journal of Animal Science, 86(9), 2135-2155. https://doi.org/10.2527/jas.2007-0826.
Girgih, A. T., He, R., Hasan, F. M., Udenigwe, C. C., Gill, T. A., & Aluko, R. E. (2015). Evaluation of the in vitro antioxidant properties of a cod (Gadus morhua) protein hydrolysate and peptide fractions. Food Chemistry, 173, 652-659. https://doi.org/10.1016/j.foodchem.2014.10.079.
Glade, M. J., & Meguid, M. M. (2015). A glance at telomeres, oxidative stress, antioxidants, and biological aging. Nutrition, 31(11-12), 1447-1451. https://doi.org/10.1016/j.nut.2015.05.018.
Görgüç, A., Gençdağ, E., & Yılmaz, F. M. (2020). Bioactive peptides derived from plant origin by-products: Hiological activities and techno-functional utilizations in food developments-A review. Food Research International, 136, 109504. https://doi.org/10.1016/j.foodres.2020.109504.
Hart, G. K., & Dobb, G. J. (1988). Effect of a fecal bulking agent on diarrhea during enteral feeding in the critically ill. Journal of Parenteral and Enteral Nutrition, 12(5), 465-468. https://doi.org/10.1177/0148607188012005465.
Hayes, M., & Bleakley, S. (2018). Peptides from plants and their applications-ScienceDirect. In S. Koutsopoulos (Ed.), Peptide applications in biomedicine, biotechnology and bioengineering, 603-622. https://doi.org/10.1016/B978-0-08-100736-5.00025-9.
He, R., Wang, Y., Yang, Y., Wang, Z., Ju, X., & Yuan, J. (2019). Rapeseed protein-derived ACE inhibitory peptides LY, RALP and GHS show antioxidant and anti-inflammatory effects on spontaneously hypertensive rats. Journal of Functional Foods, 55, 211-219. https://doi.org/10.1016/j.jff.2019.02.031.
Hu, C. H., Xiao, K., Luan, Z. S., & Song, J. (2013). Early weaning increases intestinal permeability, alters expression of cytokine and tight junction proteins, and activates mitogen-activated protein kinases in pigs. Journal of Animal Science, 91(3), 1094-1101. https://doi.org/10.2527/jas.2012-5796.
Jang, A., Liu, X. D., Shin, M. H., Lee, B. D., Lee, S. K., Lee, J. H., & Jo, C. (2008). Antioxidative potential of raw breast meat from broiler chicks fed a dietary medicinal herb extract mix. Poultry Science, 87(11), 2382-2389. https://doi.org/10.3382/ps.2007-00506.
Karimzadeh, S., Rezaei, M., & Yansari, A. T. (2016). Effects of canola bioactive peptides on performance, digestive enzyme activities, nutrient digestibility, intestinal morphology and gut microflora in broiler chickens. Poultry Science Journal, 4(1), 27-36. http://psj.gau.ac.ir.
Kenworthy, R., & Crabb, W. E. (1963). The intestinal flora of young pigs, with reference to early weaning, Escherichia coli and scours. Journal of Comparative Pathology and Therapeutics, 73, 215-228. https://doi.org/10.1016/s0368-1742(63)80025-9.
Kim, M. H., Lee, E. J., Cheon, J. M., Nam, K. J., Oh, T. H., & Kim, K. S. (2016). Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats. Laboratory Animal Research, 32(4), 217-223. https://doi.org/10.5625/lar.2016.32.4.217.
Landy, N., Kheiri, F., & Faghani, M. (2021). Evaluation of cottonseed bioactive peptides on growth performance, carcase traits, immunity, total antioxidant activity of serum and intestinal morphology in broiler chickens. Chinese Journal of Animal Nutrition, 1, 134-141. https://doi.org/10.1080/1828051X.2020.1844085.
Lauridsen, C. (2020). Effects of dietary fatty acids on gut health and function of pigs pre- and post-weaning. Journal of Animal Science, 98(4):skaa086. https://doi.org/10.1093/jas/skaa086.
Limdi, J. K. (2003). Evaluation of abnormal liver function tests. Postgraduate Medical Journal, 79(932), 307-312. https://doi.org/10.1136/pmj.79.932.307.
Liu, C. S., Liang, X., Wei, X. H., Jin, Z., Chen, F. L., Tang, Q. F., & Tan, X. M. (2019). Gegen Qinlian decoction treats diarrhea in piglets by modulating gut microbiota and short-chain fatty acids. Frontiers in Microbiology, 10, 825. https://doi.org/10.3389/fmicb.2019.00825.
Meisel, H. (2007). Editorial [Hot topic: Food-derived bioactive proteins and peptides as potential components of nutraceuticals. In H. Meisel. Executive Editor, Current pharmaceutical design (13(9), pp. 873-874. https://doi.org/10.2174/138161207780363103.
Piva, A., Casadei, G., & Biagi, G. (2002). An organic acid blend can modulate swine intestinal fermentation and reduce microbial proteolysis. Canadian Journal of Animal Science, 82(4), 527-532. https://doi.org/10.1252/kakoronbunshu.33.154.
Qiu, Y. L., Wan, L. L., Wei, B. D., Liu, H. Y., Wei, Y. U., Lin, L. I., & Chen, Q. (2011). Effect of dietary soybean active peptides on growth performance,blood indexes and antioxidation in the piglet. Animal Husbandry & Veterinary Medicine,2011, 43(7), 22-25. https://en.cnki.com.cn/Article_en/CJFDTotal-XMYS201107006.htm.
Robbins, K. R., Norton, H. W., & Baker, D. H. (1979). Estimation of nutrient requirements from growth data. The Journal of Nutrient, 109(10), 1710-1714. https://doi.org/10.1093/jn/109.10.1710.
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021). Neuromodulation by the immune system: A focus on cytokines. Nature Reviews Immunology, 21(8), 526-541. https://doi.org/10.1038/s41577-021-00508-z.
Shao, Z., & Zai-Bin, Y. (2008). Effect of plant small peptides on blood biochemical indexes and gut flora of suckling piglets. Chinese Journal of Animal Nutrition,2008, 20(1), 40-45. https://en.cnki.com.cn/Article_en/CJFDTotal-DWYX200801009.htm.
Souza, K. L. A., Gurgul-Convey, E., Elsner, M., & Lenzen, S. (2008). Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells. Journal of Endocrinology, 197(1), 139-150. https://doi.org/10.1677/joe-07-0638.
Wan, J., Zhang, J., Chen, D., Yu, B., & He, J. (2017). Effects of alginate oligosaccharide on the growth performance, antioxidant capacity and intestinal digestion-absorption function in weaned pigs. Animal Feed Science & Technology, 234, 118-127. https://doi.org/10.1016/j.anifeedsci.2017.09.006.
Wang, Y., Li, Y., Ruan, S., Lu, F., Tian, W., & Ma, H. (2021). Antihypertensive effect of rapeseed peptides and their potential in improving the effectiveness of captopril. Journal of the Science of Food and Agriculture, 101(7), 3049-3055. https://doi.org/10.1002/jsfa.10939.
Woof, J. M., & Kerr, M. A. (2006). The function of immunoglobulin A in immunity. The Journal of Pathology, 208(2), 270-282. https://doi.org/10.1002/path.1877.
Xiong, X., Tan, B., Song, M., Ji, P., Kim, K., Yin, Y., & Liu, Y. (2019). Nutritional intervention for the intestinal development and health of weaned pigs. Frontiers in Veterinary Science, 6, 46. https://doi.org/10.3389/fvets.2019.00046.
Yi, G., Din, J., Zhao, F., & Liu, X. (2020). Effect of soybean peptides against hydrogen peroxide induced oxidative stress in HepG2 cells via Nrf2 signaling. Food & Function, 11(3), 2725-2737. https://doi.org/10.1039/c9fo01466g.
Zhang, J., Chen, X., Liu, P., Zhao, J., Sun, J., Guan, W., Johnston, L. J., Levesque, C. L., Fan, P., He, T., Zhang, G., & Ma, X. (2018). Dietary Clostridium butyricum induces a phased shift in fecal microbiota structure and increases the acetic acid-producing bacteria in a weaned piglet model. Journal of Agricultural and Food Chemistry, 66(20), 5157-5166. https://doi.org/10.1021/acs.jafc.8b01253.
Zhang, J., Li, W., Ying, Z., Zhao, D., Yi, G., Li, H., & Liu, X. (2020). Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors. Food & Nutrition Research, 64, 3677. https://doi.org/10.29219/fnr.v64.3677.
Zheng, L., Park, I., & Kim, S. W. (2016). 106 Effects of supplemental soy peptide on growth performance and gut health of nursery pigs. Journal of Animal Science, 94(suppl_2), 49. https://doi.org/10.2527/msasas2016-106.
Zhou, J., Xiong, X., Wang, K., Zou, L., Lv, D., & Yin, Y. (2017). Ethanolamine metabolism in the mammalian gastrointestinal tract: Mechanisms, patterns, and importance. Current Molecular Medicine, 17(2), 92-99. https://doi.org/10.2174/1566524017666170331161715.

CARS-35 Special funds for modern agricultural industrial technology construction; cstc2019jscx-msxmX0391 Chongqing Research Program of Technological Innovation and Application Demonstration; 16202 Innovation Team Development and utilization of feed resources

Keywords: bacterial community; biochemical parameters; diarrhoea; rapeseed peptide; weanling pig

0 (Peptides)

Date Created: 20221221 Date Completed: 20230505 Latest Revision: 20230505

20230506

10.1111/jpn.13796

36541276