[RNA m 6 A Modification and Its Roles in Immune Function Regulation].

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  • Additional Information
    • Source:
      Publisher: Sichuan da xue xue bao (yi xue ban) bian ji bu Country of Publication: China NLM ID: 101162609 Publication Model: Print Cited Medium: Print ISSN: 1672-173X (Print) Linking ISSN: 1672173X NLM ISO Abbreviation: Sichuan Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE
    • Publication Information:
      Original Publication: Chengdu Shi : Sichuan da xue xue bao (yi xue ban) bian ji bu, 2003-
    • Subject Terms:
      RNA* ; Immunity*/genetics; Cytoplasm
    • Abstract:
      N 6 -methyladenosine (m 6 A) is the most prevalent post-transcriptional RNA modification in eukaryotic cells. m 6 A methyltransferase complexes and demethylases are involved in the dynamic and reversible regulation of m 6 A modification, while m 6 A binding proteins could specifically identify m 6 A modification and regulate RNA metabolism, including splicing, translocation, stability, and translation. m 6 A is found to play a vital role in all the fundamental biological processes, including the regulation of the immune system, from normal development to diseases. The normal development and functioning of the immune system rely on the precise regulation of the relevant gene expression, and m 6 A modification is crucial to the regulation. Herein, we reviewed the concept, the functions, and the mechanism of m 6 A modification, concentrating on its role in immune system function modulation. Furthermore, we highlighted present obstacles and future research directions in the field, intending to provide a theoretical foundation and reference for future study on how m 6 A modification is involved in immune regulation.
      (Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences).)
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    • Contributed Indexing:
      Keywords: Immunoregulation; N6-methyladenosine; RNA modification
    • Accession Number:
      63231-63-0 (RNA)
    • Publication Date:
      Date Created: 20221128 Date Completed: 20221130 Latest Revision: 20230829
    • Publication Date:
      20240829
    • Accession Number:
      PMC10408978
    • Accession Number:
      10.12182/20221160511
    • Accession Number:
      36443062