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Genetic variation in fatty acid amide hydrolase (FAAH): Associations with early drinking and smoking behaviors.
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- Additional Information
- Source:
Publisher: Elsevier Science Country of Publication: England NLM ID: 7603486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6327 (Electronic) Linking ISSN: 03064603 NLM ISO Abbreviation: Addict Behav Subsets: MEDLINE
- Publication Information:
Publication: Oxford : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
- Subject Terms:
- Abstract:
Background: The endocannabinoid system is implicated in psychiatric disorders and drug dependence. Within this system, fatty acid amide hydrolase (FAAH) metabolizes endocannabinoids. Individuals with A-group genotypes (C/A or A/A) of a common FAAH variant (rs324420; C > A; Pro129Thr) have slower enzymatic activity compared to C-group individuals (C/C genotype). Slow FAAH activity is differentially associated with alcohol and nicotine use.
Methods: Among European-ancestry participants in the NDIT study (n = 249-607), genotype associations with past-year binge drinking in young adults were estimated in logistic regression models. In adolescents, hazard ratios (HR) were estimated from Cox proportional hazards models to assess the FAAH genotype group association with time to drinking initiation and attaining drinking frequency outcomes. HR were also used to assess genotype effect on time to smoking initiation and attaining early smoking milestones (e.g., first inhalation, ICD-10 dependence).
Results: Compared to those in the C-group, those in the A-group had higher odds of binge drinking at ages 20 (Odds ratio (OR) = 2.16, 95 % CI 1.36-3.42) and 30 (OR = 1.61, 95 % CI 1.10-2.36). Time to initiation of drinking and daily drinking was faster in adolescents in the A-group (HR = 1.39, 95 % CI 1.09-1.77 and HR = 2.24, 95 % CI 1.05-4.76, respectively). Time to smoking initiation was faster in the A-group (HR = 1.20, 95 % CI 1.04-1.39); however, time to smoking milestones among adolescent smokers was not consistently different for the A- versus C-groups (HR = 0.43 to 1.13).
Conclusions: Slow FAAH activity (A-group) was associated with greater risks for binge drinking, drinking initiation and escalation, and cigarette smoking initiation, but had little impact on the escalation in cigarette smoking behaviors.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Tyndale has consulted for Quinn Emanuel and Ethismos Research Inc prior to 2020. The remaining co-authors declare no conflicts of interest.
(Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved.)
- Contributed Indexing:
Keywords: Adolescents; Alcohol; Binge drinking; FAAH; Genetics; Longitudinal; Smoking
- Accession Number:
EC 3.5.- (Amidohydrolases)
3K9958V90M (Ethanol)
EC 3.5.1.- (fatty-acid amide hydrolase)
- Publication Date:
Date Created: 20221120 Date Completed: 20221206 Latest Revision: 20230217
- Publication Date:
20240829
- Accession Number:
10.1016/j.addbeh.2022.107545
- Accession Number:
36403489
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