Mitochondrial Replacement Therapy: In Whose Interests?

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Cambridge University Press Country of Publication: England NLM ID: 9315583 Publication Model: Print Cited Medium: Internet ISSN: 1748-720X (Electronic) Linking ISSN: 10731105 NLM ISO Abbreviation: J Law Med Ethics
    • Publication Information:
      Publication: 2021- : [Cambridge] : Cambridge University Press
      Original Publication: Boston, MA : American Society of Law, Medicine & Ethics
    • Subject Terms:
      Mitochondrial Replacement Therapy* ; Mitochondrial Diseases*/genetics ; Mitochondrial Diseases*/prevention & control; Humans ; Mitochondria/genetics ; Australia ; United Kingdom
    • Abstract:
      Mitochondrial replacement therapy (MRT), also called nuclear genome transfer and mitochondrial donation, is a new technique that can be used to prevent the transmission of mitochondrial DNA diseases. Apart from the United Kingdom, the first country to approve MRT in 2015, Australia became the second country with a clear regulatory path for the clinical applications of this technique in 2021. The rapidly evolving clinical landscape of MRT makes the elaboration and evaluation of the responsible use of this technology a pressing matter. As jurisdictions with less strict or non-existent reproductive laws are continuing to use MRT in the clinical context, the need to address the underlying ethical issues surrounding MRT's clinical translation is fundamental.
    • References:
      J Law Biosci. 2016 Nov 22;3(3):726-735. (PMID: 28852552)
      Bioethics. 2017 Jan;31(1):7-19. (PMID: 27973718)
      Bioethics. 2015 Nov;29(9):631-8. (PMID: 26481204)
      J Biol Chem. 2019 Apr 5;294(14):5386-5395. (PMID: 29233888)
      Ann Neurol. 2015 May;77(5):753-9. (PMID: 25652200)
      Trends Mol Med. 2015 Feb;21(2):68-76. (PMID: 25573721)
      Cell. 2020 Apr 2;181(1):168-188. (PMID: 32220313)
      Pract Neurol. 2020 Aug;20(4):260-261. (PMID: 32680831)
      Nature. 2016 Dec 8;540(7632):270-275. (PMID: 27919073)
      New Bioeth. 2018 Apr;24(1):57-73. (PMID: 29529980)
      J Law Biosci. 2017 Mar 23;4(1):50-69. (PMID: 28852557)
      J Med Ethics. 2018 Dec;44(12):865-867. (PMID: 29802119)
      J Obstet Gynaecol Can. 2017 Oct;39(10):916-918. (PMID: 28733061)
      Nat Genet. 2008 Dec;40(12):1484-8. (PMID: 19029901)
      J Med Ethics. 2019 Apr;45(4):280-281. (PMID: 30463932)
      Reprod Biomed Online. 2013 Jun;26(6):531-4. (PMID: 23608245)
      Reprod Biomed Online. 2018 Jun;36(6):686-697. (PMID: 29598846)
      J Med Ethics. 2018 Dec;44(12):835-842. (PMID: 29491042)
    • Grant Information:
      157936 Canada CIHR
    • Contributed Indexing:
      Keywords: Genetic Relatedness; MRT; Mitochondrial Replacement Therapy; Reproductive Autonomy
    • Publication Date:
      Date Created: 20221118 Date Completed: 20221121 Latest Revision: 20221215
    • Publication Date:
      20221215
    • Accession Number:
      PMC9679582
    • Accession Number:
      10.1017/jme.2022.98
    • Accession Number:
      36398634