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ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population.
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- Additional Information
- Source:
Publisher: Taylor & Francis Country of Publication: England NLM ID: 0404024 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-5033 (Electronic) Linking ISSN: 03014460 NLM ISO Abbreviation: Ann Hum Biol Subsets: MEDLINE
- Publication Information:
Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: London, Taylor & Francis.
- Subject Terms:
- Abstract:
Background: Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs. Genetic polymorphisms of these transporters have effect on transporter activity. There is significant interethnic variability in the frequency of allele variants.
Aim: To determined allele and genotype frequencies of ABCG2 and SLCO1B1 genes in Croatian populations of European descent.
Subjects and Methods: A total of 905 subjects (482 women) were included. Genotyping for ABCG2 c.421C > A (rs2231142) and for SLCO1B1 c.521T > C (rs4149056), was performed by real-time polymerase chain reaction (PCR) using TaqMan ® DME Genotyping Assays.
Results: For ABCG2 c.421C > A, the frequency of CC, CA and AA genotypes was 81.4%, 17.8% and 0.8% respectively. The frequency of variant ABCG2 421 A allele was 9.7%. For SLCO1B1 c.521T > C, the frequency of TT, TC and CC genotypes was 61.7%, 34.8% and 3.5% respectively. The frequency of variant SLCO1B1 521 C allele was 20.9%.
Conclusion: The frequency of the ABCG2 and SLCO1B1 allelic variants and genotypes in the Croatian population is in accordance with other European populations. Pharmacogenetic analysis can serve to individualise drug therapy and minimise the risk of developing adverse drug reactions.
- Contributed Indexing:
Keywords: ABCG2; Croatian population; SLCO1B1; drug transporters; gene polymorphism
- Accession Number:
0 (ABCG2 protein, human)
0 (ATP Binding Cassette Transporter, Subfamily G, Member 2)
0 (Liver-Specific Organic Anion Transporter 1)
0 (Neoplasm Proteins)
0 (SLCO1B1 protein, human)
- Publication Date:
Date Created: 20221116 Date Completed: 20230306 Latest Revision: 20230306
- Publication Date:
20240829
- Accession Number:
10.1080/03014460.2022.2140826
- Accession Number:
36382878
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