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Linking Diabetes to Alzheimer's Disease: Potential Roles of Glucose Metabolism and Alpha-Glucosidase.
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- Author(s): Wee AS;Wee AS;Wee AS; Nhu TD; Nhu TD; Khaw KY; Khaw KY; Tang KS; Tang KS; Yeong KY; Yeong KY; Yeong KY
- Source:
Current neuropharmacology [Curr Neuropharmacol] 2023; Vol. 21 (10), pp. 2036-2048.- Publication Type:
Review; Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101157239 Publication Model: Print Cited Medium: Internet ISSN: 1875-6190 (Electronic) Linking ISSN: 1570159X NLM ISO Abbreviation: Curr Neuropharmacol Subsets: MEDLINE
- Publication Information: Original Publication: Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2003-
- Subject Terms: Alzheimer Disease*/etiology ; Alzheimer Disease*/metabolism ; Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/metabolism ; Hyperglycemia*/complications ; Hyperglycemia*/metabolism; Animals ; alpha-Glucosidases/metabolism ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Glucose/metabolism
- Abstract: Alzheimer's disease (AD) and type 2 diabetes mellitus (DM) are more prevalent with ageing and cause a substantial global socio-economic burden. The biology of these two conditions is well elaborated, but whether AD and type 2 DM arise from coincidental roots in ageing or are linked by pathophysiological mechanisms remains unclear. Research findings involving animal models have identified mechanisms shared by both AD and type 2 DM. Deposition of β-amyloid peptides and formation of intracellular neurofibrillary tangles are pathological hallmarks of AD. Type 2 DM, on the other hand, is a metabolic disorder characterised by hyperglycaemia and insulin resistance. Several studies show that improving type 2 DM can delay or prevent the development of AD, and hence, prevention and control of type 2 DM may reduce the risk of AD later in life. Alpha-glucosidase is an enzyme that is commonly associated with hyperglycaemia in type 2 DM. However, it is uncertain if this enzyme may play a role in the progression of AD. This review explores the experimental evidence that depicts the relationship between dysregulation of glucose metabolism and AD. We also delineate the links between alpha-glucosidase and AD and the potential role of alpha-glucosidase inhibitors in treating AD.
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Neuroscience. 2016 Feb 19;315:162-74. (PMID: 26701291) - Contributed Indexing: Keywords: Alpha-glucosidase; Alzheimer’s disease; amyloid beta-peptides; apolipoprotein E; diabetes mellitus; hyperglycaemia; tau proteins
- Accession Number: EC 3.2.1.20 (alpha-Glucosidases)
0 (Amyloid beta-Peptides)
IY9XDZ35W2 (Glucose) - Publication Date: Date Created: 20221114 Date Completed: 20230823 Latest Revision: 20240216
- Publication Date: 20240216
- Accession Number: PMC10556372
- Accession Number: 10.2174/1570159X21999221111102343
- Accession Number: 36372924
- Source:
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