Recent Advances on Natural Aryl- C -glycoside Scaffolds: Structure, Bioactivities, and Synthesis-A Comprehensive Review.

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  • Author(s): Liu CF;Liu CF
  • Source:
    Molecules (Basel, Switzerland) [Molecules] 2022 Nov 01; Vol. 27 (21). Date of Electronic Publication: 2022 Nov 01.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, c1995-
    • Subject Terms:
      Antioxidants*/pharmacology ; Antioxidants*/chemistry ; Cardiac Glycosides*; Glycosides/chemistry ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/chemistry ; Anti-Inflammatory Agents/pharmacology
    • Abstract:
      Aryl- C -glycosides, of both synthetic and natural origin, are of great significance in medicinal chemistry owing to their unique structures and stability towards enzymatic and chemical hydrolysis as compared to O -glycosides. They are well-known antibiotics and potent enzyme inhibitors and possess a wide range of biological activities such as anticancer, antioxidant, antiviral, hypoglycemic effects, and so on. Currently, a number of aryl- C -glycoside drugs are on sale for the treatment of diabetes and related complications. This review summarizes the findings on aryl- C -glycoside scaffolds over the past 20 years, concerning new structures (over 200 molecules), their bioactivities-including anticancer, anti-inflammatory, antioxidant, antivirus, glycation inhibitory activities and other pharmacological effects-as well as their synthesis.
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    • Grant Information:
      21762004 National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: aryl-C-glycoside; bioactivity; novel structures; synthesis
    • Accession Number:
      0 (C-glycoside)
      0 (Antioxidants)
      0 (Glycosides)
      0 (Hypoglycemic Agents)
      0 (Anti-Inflammatory Agents)
      0 (Cardiac Glycosides)
    • Publication Date:
      Date Created: 20221111 Date Completed: 20221114 Latest Revision: 20221117
    • Publication Date:
      20221213
    • Accession Number:
      PMC9654268
    • Accession Number:
      10.3390/molecules27217439
    • Accession Number:
      36364266