Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients.

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  • Additional Information
    • Source:
      Publisher: Blackwell Science Country of Publication: England NLM ID: 0243704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-4632 (Electronic) Linking ISSN: 00119059 NLM ISO Abbreviation: Int J Dermatol Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford : Blackwell Science
      Original Publication: Philadelphia, Lippincott.
    • Subject Terms:
      HSP70 Heat-Shock Proteins*/genetics ; HSP70 Heat-Shock Proteins*/metabolism ; Vitiligo*/genetics; Humans ; Genotype ; Polymorphism, Restriction Fragment Length ; Alleles ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide
    • Abstract:
      Background: Vitiligo is an autoimmune disease that courses with skin depigmentation because of the destruction of melanocytes. Vitiliginous melanocyte is prone to damage because of oxidative stress which activates cellular stress response and the release of heat shock proteins such as HSP70 promoting immune activation against the melanocyte. Variants in HSP70 genes (HSPA) might alter their expression and thus modulate vitiligo susceptibility. Therefore, we sought to evaluate the role of the 5' untranslated region HSPA1A G/C (rs1043618) and the exonic HSPA1B A/G (rs1061581) and HSPA1L T/C (rs2227956) gene variants in nonsegmental vitiligo.
      Methods: A total of 200 nonsegmental vitiligo patients and 208 age/gender-matched healthy subjects were genotyped for rs1043618, rs1061581, and rs2227956 variants by PCR-RFLP.
      Results: Variants rs1043618 and rs1061581 were not associated with vitiligo susceptibility. On the other hand, the rs2227956 C allele and TC genotype were associated with protection against vitiligo. A similar effect was observed for the GAC haplotype. Any of the aforementioned HSP70 gene variants were associated with the clinical characteristics of vitiligo.
      Conclusion: Our findings suggest that the HSPA1L rs2227956 gene variant might influence the susceptibility to vitiligo. Being the first study of HSP70 gene variants in vitiligo, further research is encouraged to corroborate these results.
      (© 2022 the International Society of Dermatology.)
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    • Accession Number:
      0 (HSP70 Heat-Shock Proteins)
    • Publication Date:
      Date Created: 20221108 Date Completed: 20230119 Latest Revision: 20230222
    • Publication Date:
      20230223
    • Accession Number:
      10.1111/ijd.16487
    • Accession Number:
      36345598