Genome-wide association study for antibody response to Mycobacterium avium ssp. paratubeculosis in goats.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 8605704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2052 (Electronic) Linking ISSN: 02689146 NLM ISO Abbreviation: Anim Genet Subsets: MEDLINE
    • Publication Information:
      Publication: Oxford, England : Wiley-Blackwell
      Original Publication: Oxford, England : Published by Blackwell Scientific Publications for the International Society for Animal Blood Group Research, c1986-
    • Subject Terms:
    • Abstract:
      Mycobacterium avium ssp. paratuberculosis (MAP), causes Johne's disease (JD), or paratuberculosis, a chronic enteritis of ruminants, which in goats is characterized by ileal lesions. The work described here is a case-control association study using the Illumina Caprine SNP50 BeadChip to unravel the genes involved in susceptibility of goats to JD. Goats in herds with a high occurrence of Johne's disease were classified as healthy or infected based on the level of serum antibodies against MAP, and 331 animals were selected for the association study. Goats belonged to the Jonica (157) and Siriana breeds (174). Whole-genome association analysis identified one region suggestive of significance associated with an antibody response to MAP on chromosome 7 (p-value = 1.23 × 10 -5 ). These results provide evidence for genetic loci involved in the antibody response to MAP in goats.
      (© 2022 Stichting International Foundation for Animal Genetics.)
    • References:
      Aulchenko, Y.S., Ripke, S., Isaacs, A. & van Duijn, C.M. (2007) GenABEL: an R package for genome-wide association analysis. Bioinformatics, 23, 1294-1296.
      Casey, M.E., Meade, K.G., Nalpas, N.C., Taraktsoglou, M., Browne, J.A., Killick, K.E. et al. (2015) Analysis of the bovine monocyte-derived macrophage response to Mycobacterium avium subspecies paratuberculosis infection using RNA-seq. Frontiers in Immunology, 6, 23.
      Cecchi, F., Russo, C., Iamartino, D., Galiero, A., Turchi, B., Fratini, F. et al. (2017) Identification of candidate genes for paratuberculosis resistance in the native Italian Garfagnina goat breed. Tropical Animal Health and Production, 49(6), 1135-1142.
      Duggal, P., Gillanders, E.M., Holmes, T.N. & Bailey-Wilson, J.E. (2008) Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies. BMC Genomics, 9, 516.
      Fernández-Silva, J.A., Correa-Valencia, N.M. & Ramírez, N.F. (2014) Systematic review of the prevalence of paratuberculosis in cattle, sheep, and goats in Latin America and the Caribbean. Tropical Animal Health and Production, 46(8), 1321-1340.
      Fiorentina, P., Martino, C., Mancini, Y., De Iorio, M.G., Williams, J.L. & Minozzi, G. (2021) Using omics approaches in the discovery of biomarkers for early diagnosis of Johne's disease in sheep and goats. Animals (Basel), 11(7), 1912.
      Galiero, A., Turchi, B., Pedonese, F., Nuvoloni, R., Cantile, C., Colombani, G. et al. (2017) Serological, culture and molecular survey of Mycobacterium avium paratuberculosis in a goat flock in Tuscany. Folia Microbiolgica (Praha), 62(6), 471-477.
      Malvisi, M., Curti, N., Remondini, D., De Iorio, M.G., Palazzo, F., Gandini, G. et al. (2020) Combinatorial discriminant analysis applied to RNAseq data reveals a set of 10 transcripts as signatures of exposure of cattle to Mycobacterium avium subsp. paratuberculosis. Animals (Basel), 10(2), 253.
      Malvisi, M., Palazzo, F., Morandi, N., Lazzari, B., Williams, J.L., Pagnacco, G. et al. (2016) Responses of bovine innate immunity to Mycobacterium avium subsp.paratuberculosis infection revealed by changes in gene expression and levels of MicroRNA. PLoS One, 11(10), e0164461.
      Marino, R., Capoferri, R., Panelli, S., Minozzi, G., Strozzi, F., Trevisi, E. et al. (2017) Johne's disease in cattle: an in vitro model to study early response to infection of Mycobacterium avium subsp. paratuberculosis using RNA-seq. Molecular Immunology, 91, 259-271.
      Nielsen, S.S. & Toft, N. (2009) A review of prevalences of paratuberculosis in farmed animals in Europe. Preventive Veterinary Medicine, 88(1), 1-14.
      Perera, N.C., Wiesmüller, K.H., Larsen, M.T., Schacher, B., Eickholz, P., Borregaard, N. et al. (2013) NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. Journal of Immunology, 191(5), 2700-2707.
      Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A. & Reich, D. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, 38(8), 904-909.
      R: The R Project for Statistical Computing. (2020) Avaialble from: http://www.r-project.org. [Accessed 10th July 2022].
      Settles, M., Zanella, R., McKay, S.D., Schnabel, R.D., Taylor, J.F., Whitlock, R. et al. (2009) A whole genome association analysis identifies loci associated with Mycobacterium avium subsp. paratuberculosis infection status in US Holstein cattle. Animal Genetics, 40(5), 655-662.
      van Hulzen, K.J., Koets, A.P., Nielen, M., Hoeboer, J., van Arendonk, J.A. & Heuven, H.C. (2012) Genetic variation for infection status as determined by a specific antibody response against Mycobacterium avium subspecies paratuberculosis in milk of Dutch dairy goats. Journal of Dairy Science, 95(10), 6145-6151.
      Windsor, P.A. (2015) Paratuberculosis in sheep and goats. Veterinary Microbioliogy, 181(1-2), 161-169.
    • Grant Information:
      201801057971 - G44I19001910002 Regione Lombardia; PON01_01841 PON EPISUD The Italian Ministry of Education and Research
    • Contributed Indexing:
      Keywords: ELISA; SNPs; caprine; genetic association; paratuberculosis
    • Publication Date:
      Date Created: 20221102 Date Completed: 20230106 Latest Revision: 20230111
    • Publication Date:
      20231215
    • Accession Number:
      10.1111/age.13271
    • Accession Number:
      36321295