Transport in the Brain Extracellular Space: Diffusion, but Which Kind?

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Extracellular Space*/metabolism ; Brain*; Diffusion ; Biological Transport ; Diffusion Magnetic Resonance Imaging

The mechanisms of transport of substances in the brain parenchyma have been a hot topic in scientific discussion in the past decade. This discussion was triggered by the proposed glymphatic hypothesis, which assumes a directed flow of cerebral fluid within the parenchyma, in contrast to the previous notion that diffusion is the main mechanism. However, when discussing the issue of "diffusion or non-diffusion", much less attention was given to the question that diffusion itself can have a different character. In our opinion, some of the recently published results do not fit into the traditional understanding of diffusion. In this regard, we outline the relevant new theoretical approaches on transport processes in complex random media such as concepts of diffusive diffusivity and time-dependent homogenization, which expands the understanding of the forms of transport of substances based on diffusion.

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22-15-00143 Russian Science Foundation; 075-15-2022-1094 Government of the Russian Federation

Keywords: brain fluids; diffusion; extracellular space

Date Created: 20221027 Date Completed: 20221028 Latest Revision: 20221030

20231215

PMC9604357

10.3390/ijms232012401

36293258