Intraoperative subconjunctival steroid reduces the incidence of pseudophakic macular oedema: a cohort study of 20,066 consecutive phacoemulsification surgeries.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8703986 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5454 (Electronic) Linking ISSN: 0950222X NLM ISO Abbreviation: Eye (Lond) Subsets: MEDLINE
    • Publication Information:
      Publication: <2003->: London : Nature Publishing Group
      Original Publication: [London : Ophthalmological Society of the United Kingdom, 1987-
    • Subject Terms:
      Cataract*/complications ; Macular Edema*/epidemiology ; Macular Edema*/etiology ; Macular Edema*/prevention & control ; Phacoemulsification*/adverse effects; Humans ; Cohort Studies ; Incidence ; Pseudophakia ; Retrospective Studies
    • Abstract:
      Background/objectives: Pseudophakic macular oedema remains the most common sight-threatening complication following cataract surgery. This study aims to assess the effect of intraoperative subconjunctival steroids on the rate of pseudophakic cystoid macular oedema.
      Methods: A retrospective, observational database study of 20 066 consecutive phacoemulsification surgeries. The incidence of pseudophakic cystoid macular oedema was compared in eyes that did and did not receive intraoperative subconjunctival steroid injection during routine cataract surgery.
      Results: Intraoperative subconjunctival injection of dexamethasone or betamethasone sodium phosphate significantly reduced the odds of developing pseudophakic cystoid macular oedema across the cohort (odds ratio: 0.67; 95% confidence interval: 0.46-0.98, p = 0.039). The effect of subconjunctival steroids on pseudophakic macular oedema remained independently associated on multivariate logistic regression analysis (p = 0.028).
      Conclusion: This study demonstrates that administration of intraoperative subconjunctival steroid injection is associated with a reduced incidence of pseudophakic cystoid macular oedema in routine, uncomplicated cataract surgery.
      (© 2022. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.)
    • References:
      J Glaucoma. 2007 Mar;16(2):251-6. (PMID: 17473740)
      Ophthalmology. 2016 Feb;123(2):316-323. (PMID: 26681390)
      Eye (Lond). 2021 Feb;35(2):584-591. (PMID: 32376978)
      Cont Lens Anterior Eye. 2009 Jun;32(3):143-4. (PMID: 19201646)
      J Cataract Refract Surg. 2019 Jan;45(1):114-115. (PMID: 30579525)
      Am J Ophthalmol. 1999 Aug;128(2):192-7. (PMID: 10458175)
      Curr Opin Ophthalmol. 2020 Jan;31(1):67-73. (PMID: 31688226)
      J Cataract Refract Surg. 2011 Sep;37(9):1589-97. (PMID: 21855759)
      Sci Rep. 2017 Oct 16;7(1):13267. (PMID: 29038497)
      Ophthalmology. 2015 Nov;122(11):2159-68. (PMID: 26123091)
      J Cataract Refract Surg. 2018 Jul;44(7):836-847. (PMID: 30055692)
      Retina. 2013 Mar;33(3):522-31. (PMID: 22990317)
      Clin Interv Aging. 2016 Sep 09;11:1221-1229. (PMID: 27672316)
      Am J Ophthalmol. 2015 Nov;160(5):968-981.e33. (PMID: 26232601)
      J Pharm Sci. 1973 Apr;62(4):617-21. (PMID: 4698983)
      Am J Ophthalmol. 2008 Apr;145(4):676-681. (PMID: 18243153)
      Acta Ophthalmol. 2020 Feb;98(1):36-42. (PMID: 31210019)
      Cornea. 2015 May;34(5):541-3. (PMID: 25826326)
      Ophthalmology. 2017 Feb;124(2):P1-P119. (PMID: 27745902)
      Arch Ophthalmol. 2000 Aug;118(8):1129-32. (PMID: 10922213)
      Eye (Lond). 1992;6 ( Pt 1):105-10. (PMID: 1426392)
      J Cataract Refract Surg. 2018 Aug;44(8):1056-1057. (PMID: 30115291)
      Acta Ophthalmol. 2014 Nov;92(7):623-8. (PMID: 24479722)
      Cochrane Database Syst Rev. 2017 Jul 03;7:CD010516. (PMID: 28670710)
      Eye (Lond). 1993;7 ( Pt 6):744-8. (PMID: 8119423)
      Br J Ophthalmol. 2009 Jun;93(6):708-13. (PMID: 19293163)
      Am J Ophthalmol. 2017 Apr;176:174-182. (PMID: 28104415)
      Ophthalmic Res. 1988;20(1):31-43. (PMID: 3380524)
      J Cataract Refract Surg. 2020 Jan;46(1):138-142. (PMID: 32050243)
      Clin Ophthalmol. 2018 Nov 01;12:2223-2235. (PMID: 30464383)
      Curr Opin Ophthalmol. 2012 Jan;23(1):26-32. (PMID: 22134362)
      Ophthalmology. 2015 Dec;122(12):2450-6. (PMID: 26409728)
      Indian J Ophthalmol. 2014 Aug;62(8):861-4. (PMID: 25230962)
      Br J Ophthalmol. 1990 Aug;74(8):477-80. (PMID: 2390523)
      Trans Ophthalmol Soc U K (1962). 1978 Apr;98(1):63-5. (PMID: 373174)
      Arch Ophthalmol. 1992 Feb;110(2):259-66. (PMID: 1736876)
      Ophthalmology. 2001 May;108(5):936-44. (PMID: 11320025)
      Can J Ophthalmol. 2006 Dec;41(6):699-703. (PMID: 17224950)
      Clin Ophthalmol. 2009;3:345-55. (PMID: 19668589)
      Lancet Glob Health. 2017 Dec;5(12):e1221-e1234. (PMID: 29032195)
    • Publication Date:
      Date Created: 20221022 Date Completed: 20230718 Latest Revision: 20240702
    • Publication Date:
      20240702
    • Accession Number:
      PMC10333298
    • Accession Number:
      10.1038/s41433-022-02290-1
    • Accession Number:
      36273040