Redox- and pH-Responsive Polymersomes with Ferrocene Moieties Exhibiting Peroxidase-like, Chemoenzymatic Activity and H 2 O 2 -Responsive Release Behavior.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4602 (Electronic) Linking ISSN: 15257797 NLM ISO Abbreviation: Biomacromolecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : American Chemical Society, c2000-
    • Subject Terms:
      Hydrogen Peroxide* ; Polymers*/pharmacology; Metallocenes ; Hydrogen-Ion Concentration ; Oxidation-Reduction ; Peroxidases
    • Abstract:
      The development of compartments for the design of cascade reactions in a local space requires a selective spatiotemporal control. The combination of enzyme-loaded polymersomes with enzymelike units shows a great potential in further refining the diffusion barrier and the type of reactions in nanoreactors. Herein, pH-responsive and ferrocene-containing block copolymers were synthesized to realize pH-stable and multiresponsive polymersomes. Permeable membrane, peroxidase-like behavior induced by the redox-responsive ferrocene moieties and release properties were validated using cyclovoltammetry, dye TMB assay, and rupture of host-guest interactions with β-cyclodextrin, respectively. Due to the incorporation of different block copolymers, the membrane permeability of glucose oxidase-loaded polymersomes was changed by increasing extracellular glucose concentration and in TMB assay, allowing for the chemoenzymatic cascade reaction. This study presents a potent synthetic, multiresponsive nanoreactor platform with tunable (e.g., redox-responsive) membrane properties for potential application in therapeutics.
    • Accession Number:
      BBX060AN9V (Hydrogen Peroxide)
      U96PKG90JQ (ferrocene)
      0 (Metallocenes)
      0 (Polymers)
      EC 1.11.1.- (Peroxidases)
    • Publication Date:
      Date Created: 20221010 Date Completed: 20221115 Latest Revision: 20221130
    • Publication Date:
      20231215
    • Accession Number:
      10.1021/acs.biomac.2c00901
    • Accession Number:
      36215725