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Orang Asli Health and Lifeways Project (OA HeLP): a cross-sectional cohort study protocol.
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- Author(s): Wallace IJ;Wallace IJ; Lea AJ; Lea AJ; Lea AJ; Lim YAL; Lim YAL; Chow SKW; Chow SKW; Chow SKW; Sayed IBM; Sayed IBM; Ngui R; Ngui R; Shaffee MTH; Shaffee MTH; Ng KS; Ng KS; Nicholas C; Nicholas C; Venkataraman VV; Venkataraman VV; Kraft TS; Kraft TS
- Source:
BMJ open [BMJ Open] 2022 Sep 20; Vol. 12 (9), pp. e058660. Date of Electronic Publication: 2022 Sep 20.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.- Language:
English - Source:
- Additional Information
- Source: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
- Publication Information: Original Publication: [London] : BMJ Publishing Group Ltd, 2011-
- Subject Terms:
- Abstract: Introduction: Non-communicable disease (NCD) risk is influenced by environmental factors that are highly variable worldwide, yet prior research has focused mainly on high-income countries where most people are exposed to relatively homogeneous and static environments. Understanding the scope and complexity of environmental influences on NCD risk around the globe requires more data from people living in diverse and changing environments. Our project will investigate the prevalence and environmental causes of NCDs among the indigenous peoples of Peninsular Malaysia, known collectively as the Orang Asli, who are currently undergoing varying degrees of lifestyle and sociocultural changes that are predicted to increase vulnerability to NCDs, particularly metabolic disorders and musculoskeletal degenerative diseases.
Methods and Analysis: Biospecimen sampling and screening for a suite of NCDs (eg, cardiovascular disease, type II diabetes, osteoarthritis and osteoporosis), combined with detailed ethnographic work to assess key lifestyle and sociocultural variables (eg, diet, physical activity and wealth), will take place in Orang Asli communities spanning a gradient from remote, traditional villages to acculturated, market-integrated urban areas. Analyses will first test for relationships between environmental variables, NCD risk factors and NCD occurrence to investigate how environmental changes are affecting NCD susceptibility among the Orang Asli. Second, we will examine potential molecular and physiological mechanisms (eg, epigenetics and systemic inflammation) that mediate environmental effects on health. Third, we will identify intrinsic (eg, age and sex) and extrinsic (eg, early-life experiences) factors that predispose certain people to NCDs in the face of environmental change to better understand which Orang Asli are at greatest risk of NCDs.
Ethics and Dissemination: Approval was obtained from multiple ethical review boards including the Malaysian Ministry of Health. This study follows established principles for ethical biomedical research among vulnerable indigenous communities, including fostering collaboration, building cultural competency, enhancing transparency, supporting capacity building and disseminating research findings.
Competing Interests: Competing interests: None declared.
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- Contributed Indexing: Keywords: Anthropology; EPIDEMIOLOGY; PUBLIC HEALTH
- Publication Date: Date Created: 20220920 Date Completed: 20220923 Latest Revision: 20221010
- Publication Date: 20221213
- Accession Number: PMC9490611
- Accession Number: 10.1136/bmjopen-2021-058660
- Accession Number: 36127083
- Source:
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