Estimating Ni, Cr, Co, and Mo release from 3 dental casting alloys in saliva and blood at 6 and 12 months by using inductively coupled plasma mass spectroscopy.

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  • Author(s): Joshi S;Joshi S; Sanyal PK; Sanyal PK; Patil JA; Patil JA
  • Source:
    The Journal of prosthetic dentistry [J Prosthet Dent] 2024 Aug; Vol. 132 (2), pp. 402-407. Date of Electronic Publication: 2022 Sep 15.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Mosby-Year Book Country of Publication: United States NLM ID: 0376364 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6841 (Electronic) Linking ISSN: 00223913 NLM ISO Abbreviation: J Prosthet Dent Subsets: MEDLINE
    • Publication Information:
      Publication: St. Louis Mo : Mosby-Year Book
      Original Publication: St. Louis, Mosby.
    • Subject Terms:
      Saliva*/chemistry ; Chromium*/analysis ; Chromium*/blood ; Nickel*/analysis ; Nickel*/blood ; Nickel*/chemistry ; Dental Alloys*/chemistry ; Cobalt*/analysis ; Cobalt*/blood; Humans ; Molybdenum/analysis ; Chromium Alloys/chemistry ; Mass Spectrometry/methods ; Female ; Male ; Middle Aged ; Aged ; Adult ; Time Factors
    • Abstract:
      Statement of Problem: The leaching of elements from long-term definitive prostheses, with saliva acting as an electrolyte, poses a biological concern. The approximate concentration in the biological samples that are considered clinically toxic ranges from 1 to 5000 nmol/L for Cr and Co, 1 to 200 nmol/L for Ni, and 1 to 20 nmol/L for Mo. While in vitro studies are available regarding the leaching of elements in artificial saliva, solutions containing protein, solutions of different pH, and different culture media, the in vivo effects of leaching in the biological sample with increasing time are unknown.
      Purpose: The purpose of this clinical study was to quantify the Ni, Co, Cr, and Mo metals in saliva and blood before and after restoration with prostheses made from 3 different brands of dental casting alloy at 6 and 12 months.
      Material and Methods: Three popular brands of Ni-Cr alloy with different compositions were evaluated. A total of 150 participants requiring a definitive prosthesis were enrolled and divided into 3 groups (n=50). Heavy metal levels from saliva and blood were measured by using the inductively coupled plasma mass spectroscopy method before cementation of the prosthesis and after 6 and 12 months.
      Results: The presence of Ni in saliva was in the range of 10.34 to 12.12 μg/L, Cr was 1.04 to 1.22 μg/L, and Mo was 1.04 to 1.08 μg/L over a period of 6 and 12 months after cementation of the metal prosthesis. The presence of Ni in blood was in the range of 6.35 to 14.45 μg/L and that of Cr was 9.09 to 16.16 μg/L over a period of 6 and 12 months after cementation. Co levels were not detected from any brands in saliva or blood, and Mo was detected only in the saliva samples.
      Conclusions: Increased levels of Ni and Cr in saliva and blood from all 3 brands of base metal alloy at 6 and 12 months were observed at higher than threshold values.
      (Copyright © 2022 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.)
    • Accession Number:
      0R0008Q3JB (Chromium)
      7OV03QG267 (Nickel)
      0 (Dental Alloys)
      3G0H8C9362 (Cobalt)
      81AH48963U (Molybdenum)
      0 (Chromium Alloys)
    • Publication Date:
      Date Created: 20220917 Date Completed: 20240802 Latest Revision: 20240802
    • Publication Date:
      20240803
    • Accession Number:
      10.1016/j.prosdent.2022.04.025
    • Accession Number:
      36115711