CYANOACRYLATE GLUE FOR GASTROESOPHAGEAL VARICES: A SINGLE CENTRE EXPERIENCE FROM NORTH INDIA.

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  • Author(s): Garg M;Garg M; Gupta T; Gupta T; Goyal S; Goyal S
  • Source:
    Arquivos de gastroenterologia [Arq Gastroenterol] 2022 Jul-Sep; Vol. 59 (3), pp. 434-438.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia Country of Publication: Brazil NLM ID: 15310600R Publication Model: Print Cited Medium: Internet ISSN: 1678-4219 (Electronic) Linking ISSN: 00042803 NLM ISO Abbreviation: Arq Gastroenterol Subsets: MEDLINE
    • Publication Information:
      Original Publication: São Paulo, Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia.
    • Subject Terms:
      Enbucrilate*/therapeutic use ; Esophageal and Gastric Varices*/complications ; Esophageal and Gastric Varices*/therapy ; Varicose Veins*/complications; Cyanoacrylates/therapeutic use ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; India ; Treatment Outcome
    • Abstract:
      Background: In natural history of cirrhosis, variceal bleeding is one of the earliest decompensations to happen, and, if adequately managed, survival is improved. Gastric varices have challenges in management due to their location, size and propensity to bleed. The N-butyl 2-cyanoacrylate (NBC) glue application has emerged as definitive therapy in bleeding gastric varices. Here we present our experience with use of NBC in management of gastric and difficult cases of esophageal varices.
      Methods: A total of 75 patients underwent NBC glue application for varices which included 69 patients with gastric varices and six patients with esophageal varices. All the procedures were done with flexible endoscope and sclerotherapy needle after due precautionary measures.
      Results: Hemostasis was varices in all patients after endotherapy. The average quantity of glue used was 2.75±0.95 mL. Complete obliteration with single session of NBC application was achieved in 55 patients. Re-bleeding occurred in five patients within 5 days of index event. 20 patients had in-hospital mortality but none was related to gastrointestinal bleeding. 6-week all-cause mortality was 26 (35%).
      Conclusion: Glue therapy with NBC is a life saving therapy in patients with bleeding gastric varices and esophageal varices not amenable to endoscopic variceal ligation or sclerotherapy.
    • Accession Number:
      0 (Cyanoacrylates)
      F8CEP82QNP (Enbucrilate)
    • Publication Date:
      Date Created: 20220914 Date Completed: 20220915 Latest Revision: 20220915
    • Publication Date:
      20240829
    • Accession Number:
      10.1590/S0004-2803.202203000-77
    • Accession Number:
      36102444