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A potential association between obesity and reduced effectiveness of COVID-19 vaccine-induced neutralizing humoral immunity.
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- Author(s): Faizo AA;Faizo AA;Faizo AA; Qashqari FS; Qashqari FS; Qashqari FS; El-Kafrawy SA; El-Kafrawy SA; El-Kafrawy SA; Barasheed O; Barasheed O; Almashjary MN; Almashjary MN; Almashjary MN; Almashjary MN; Alfelali M; Alfelali M; Bawazir AA; Bawazir AA; Bawazir AA; Albarakati BM; Albarakati BM; Khayyat SA; Khayyat SA; Hassan AM; Hassan AM; Hassan AM; Alandijany TA; Alandijany TA; Alandijany TA; Azhar EI; Azhar EI; Azhar EI
- Source:
Journal of medical virology [J Med Virol] 2023 Jan; Vol. 95 (1), pp. e28130. Date of Electronic Publication: 2022 Sep 14.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
- Publication Information: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss. - Subject Terms:
- Abstract: Due to the adverse effects of obesity on host immunity, this study investigated the effectiveness of COVID-19 vaccines (BNT162b2, ChAdOx-nCov-2019, and mRNA-1273) in inducing anti-SARS-CoV-2 Spike (S) neutralizing antibodies among individuals with various obesity classes (class I, II, III, and super obesity). Sera from vaccinated obese individuals (n = 73) and normal BMI controls (n = 46) were subjected to S-based enzyme-linked immunosorbent assay (ELISA) and serum-neutralization test (SNT) to determine the prevalence and titer of anti-SARS-CoV-2 neutralizing antibodies. Nucleocapsid-ELISA was also utilized to distinguish between immunity acquired via vaccination only versus vaccination plus recovery from infection. Data were linked to participant demographics including age, gender, past COVID-19 diagnosis, and COVID-19 vaccination profile. S-based ELISA demonstrated high seroprevalence rates (>97%) in the study and control groups whether samples with evidence of past infection were included or excluded. Interestingly, however, SNT demonstrated a slightly significant reduction in both the rate and titer of anti-SARS-CoV-2 neutralizing antibodies among vaccinated obese individuals (60/73; 82.19%) compared to controls (45/46; 97.83%). The observed reduction in COVID-19 vaccine-induced neutralizing humoral immunity among obese individuals occurs independently of gender, recovery from past infection, and period from last vaccination. Our data suggest that COVID-19 vaccines are highly effective in inducing protective humoral immunity. This effectiveness, however, is potentially reduced among obese individuals which highlight the importance of booster doses to improve their neutralizing immunity. Further investigations on larger sample size remain necessary to comprehensively conclude about the effect of obesity on COVID-19 vaccine effectiveness on humoral immunity induction.
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- Accession Number: 0 (COVID-19 Vaccines)
0 (BNT162 Vaccine)
0 (Antibodies, Neutralizing)
0 (Antibodies, Viral) - Publication Date: Date Created: 20220906 Date Completed: 20230110 Latest Revision: 20230208
- Publication Date: 20230208
- Accession Number: PMC9539352
- Accession Number: 10.1002/jmv.28130
- Accession Number: 36068377
- Source:
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