CONCEPTE ACTUALE PRIVIND LMNH LA COPIL.

Modern Concepts of Childhood Non-Hodgkin Lymphoma.

The lymphomas are malignant transformations which can occur in any of the morphologically and functionally distinct subpopulations of lymphoid cells of the immune system and in any of the central or peripheral lymphoid organs, which accounts for the heterogeneity of morphologic, immunologic and clinical features observed in malignant lymphomas, as well as the incidence of generalized disease. Cytogenetic studies of lymphomas have provided some of the most exciting clues to the pathogenesis of these diseases. The application oh immunodiagnostic techniques to the diagnosis oh NHL has allowed more accurate identification of the lineage and thus the cell of origin of NHL. The most important advances in treatment of childhood NHL resulted from the recognition of the systemic nature of these diseases and their potential for rapid dissemination even from apparently localized sites of disease. [ABSTRACT FROM AUTHOR]

Limfoamele reprezintӑ afecţiuni maligne care intereseazӑ celulele şi organele sistemului imun. Transformarea malignӑ poate apӑrea în oricare subpopulaţie morfologicӑ şi funcţionalӑ distinctӑ de celule limfocitare ale sistemului imun şi în oricare organ limfoid central sau periferic, ceea ce conduce la heterogenitatea morfologicӑ, imunologicӑ şi clinicӑ a limfoamelor maligne, ca şi frecvenţa crescutӑ a bolii diseminate. În ultimii ani, prin studii citogenetice, s-au fӑcut progrese mari privind patogenia acestor afecţiuni. Utilizarea tehnicilor de imunodiagnostic a LMNH a permis identificarea mai precisӑ a lineajului (celule de origine a limfomului). Recunoaşterea naturii sistemice a bolii şi a potenţialului de diseminare rapidӑ stӑ la baza celor mai importante progrese terapeutice în LMNH la copil, prin adoptarea chimioterapiei sistemice. [ABSTRACT FROM AUTHOR]

Copyright of Romanian Journal of Pediatrics / Revista Romana de Pediatrie is the property of Amaltea Medical Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)