Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea.

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  • Additional Information
    • Source:
      Publisher: The Korean Society for Parasitology and Tropical Medicine Country of Publication: Korea (South) NLM ID: 9435800 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1738-0006 (Electronic) Linking ISSN: 00234001 NLM ISO Abbreviation: Korean J Parasitol Subsets: MEDLINE
    • Publication Information:
      Publication: 2015-2022: Sŏul : The Korean Society for Parasitology and Tropical Medicine
      Original Publication: Seoul, Korea : Korean Society for Parasitology, c1993-2022.
    • Subject Terms:
      Bile Duct Neoplasms*/epidemiology ; Cholangiocarcinoma*/epidemiology ; Cholangiocarcinoma*/pathology ; Clonorchiasis*/epidemiology ; Clonorchiasis*/pathology ; Clonorchis sinensis*; Adult ; Animals ; Bile Ducts, Intrahepatic/pathology ; Humans ; Republic of Korea/epidemiology
    • Abstract:
      This study provides an overview of the current status of clonorchiasis and cholangiocarcinoma (CCA), and their relationship in Korea during 2012-2020. Data were obtained from the Health Insurance Review & Assessment Service of Korea. Cluster, trend, and correlation analyses were performed. Gyeongsangnam-do and Seoul had the highest average number of cases (1,026 and 4,208) and adjusted rate (306 and 424) for clonorchiasis and CCA, respectively. The most likely clusters (MLC) for clonorchiasis and CCA were Busan/Gyeongsangnam-do/Ulsan/Daegu/Gyeongsangbuk-do (Relative Risk; RR = 4.55, Likelihood Ratio; LLR = 9,131.115) joint cluster and Seoul (RR = 2.29, LLR = 7,602.472), respectively. The MLC for clonorchiasis was in the southeastern part of Korea, while that for CCA was in the southern part. Clonorchiasis showed a decreasing trend in the southeastern districts, while increased in the southwestern districts. Cities in the central region had a decreasing trend, while the western districts had an increasing trend. In most adults (30-59), infection rate of clonorchiasis showed a significant decrease until 2018, while thereafter increased, although not significant. CCA showed a sharply decreasing tendency. The incidence of clonorchiasis and CCA were positively correlated. In general, the correlation was weak (r = 0.39, P < 0.001), but it was strongly positive around the 4 river basins (r = 0.74, P < 0.001). This study might provide an analytic basis for developing an effective system against clonorchiasis and CCA.
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    • Grant Information:
      2015-01 Korean Association of Health Promotion
    • Contributed Indexing:
      Keywords: Clonorchiasis; HIRA; SaTScan; cholangiocarcinoma; cluster; spatiotemporal analysis
    • Publication Date:
      Date Created: 20220830 Date Completed: 20220901 Latest Revision: 20220913
    • Publication Date:
      20250114
    • Accession Number:
      PMC9441450
    • Accession Number:
      10.3347/kjp.2022.60.4.261
    • Accession Number:
      36041488