Filling gaps between exposure modeling and the analysis of urinary biomarkers using personal air monitoring: An intervention study of permethrin used in home insecticide spray.

Publisher: Blackwell Country of Publication: England NLM ID: 9423515 Publication Model: Print Cited Medium: Internet ISSN: 1600-0668 (Electronic) Linking ISSN: 09056947 NLM ISO Abbreviation: Indoor Air Subsets: MEDLINE

Publication: Oxford : Blackwell
Original Publication: Copenhagen : Danish Technical Press, c1991-

Air Pollution, Indoor* ; Insecticides*/metabolism ; Pyrethrins*/metabolism; Biomarkers ; Environmental Monitoring ; Humans ; Permethrin/metabolism

Permethrin is one of the most widely used active ingredients in spray-type home insecticides. However, indoor permethrin exposure resulting from the use of home insecticides is not well-characterized, as measured permethrin concentrations in indoor environmental and biological media with a known application rate are scarce. We conducted an intervention study with four participants for seven days. We conducted personal air monitoring and collected 24-h urine samples in which we quantified time-weighted average (TWA) permethrin concentrations in indoor air (C air ) and urinary concentrations of two permethrin metabolites, 3-phenoxybenzoic acid (3-PBA) and cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis/trans-DCCA). We also estimated (1) TWA C air using a simple indoor air model and (2) urinary excreted (UE) mass using a simple excretion model with both estimated and measured TWA C air . Measurements of TWA C air from personal air monitoring were lower than those estimated from the indoor model by a factor of 2.9 to 49.4. The ratio of estimated to measured UE mass ranged 3.5-18.2 when using estimated TWA C air and 1.1-2.9 when using measured TWA C air . Smaller ratios in estimating internal permethrin exposure from personal air monitoring suggest that personal air monitoring could reduce uncertainties in permethrin exposure assessment resulting from the use of spray-type insecticides.
(© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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Keywords: air monitoring; exposure modeling; home insecticide; indoor air modeling; intervention study; permethrin

0 (Biomarkers)
0 (Insecticides)
0 (Pyrethrins)
509F88P9SZ (Permethrin)

Date Created: 20220830 Date Completed: 20220902 Latest Revision: 20221028

20240829

10.1111/ina.13090

36040288