PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells.

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  • Additional Information
    • Source:
      Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel, Switzerland : MDPI, 2011-
    • Subject Terms:
      Decidua*/metabolism ; Stromal Cells*/metabolism; Forkhead Box Protein O1/*genetics ; Receptors, Progesterone/*metabolism; Cells, Cultured ; Cellular Senescence ; Female ; Forkhead Box Protein O1/metabolism ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Pregnancy ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism
    • Abstract:
      The appropriate differentiation of endometrial stromal cells (ESCs) into decidual cells is required for embryo implantation and subsequent placentation into humans. Decidualization is accompanied by the appearance of senescent-like cells. We recently reported the secretory phase-specific downregulation of endometrial progesterone receptor membrane component 1 (PGRMC1) and enhanced decidualization upon PGRMC1 knockdown and inhibition in cultured ESCs. However, it remains unknown whether PGRMC1 is involved in cellular senescence during decidualization. Here, we showed that the small interfering RNA (siRNA)-mediated knockdown of PGRMC1 and the inhibition of PGRMC1 by AG-205 increased the expression of the transcription factor forkhead box protein O1 (FOXO1) and the senescence-associated β-galactosidase activity in cAMP analog- and progesterone-treated ESCs. Furthermore, the knockdown of FOXO1 repressed the decidual senescence induced by siRNA-based PGRMC1 knockdown or AG-205 treatment. Taken together, the decreased PGRMC1 expression in ESCs may accelerate decidualization and cellular senescence via the upregulation of FOXO1 expression for appropriate endometrial remodeling and embryo implantation during the secretory phase.
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    • Contributed Indexing:
      Keywords: PGRMC1; decidualization; senescence
    • Accession Number:
      0 (FOXO1 protein, human)
      0 (Forkhead Box Protein O1)
      0 (Membrane Proteins)
      0 (PGRMC1 protein, human)
      0 (RNA, Small Interfering)
      0 (Receptors, Progesterone)
    • Publication Date:
      Date Created: 20220826 Date Completed: 20220829 Latest Revision: 20220913
    • Publication Date:
      20221213
    • Accession Number:
      PMC9405960
    • Accession Number:
      10.3390/biom12081046
    • Accession Number:
      36008941