Year-long effects of COVID-19 restrictions on glycemic control and body composition in patients with glucose intolerance in Japan: A single-center retrospective study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Asian Association for the Study of Diabetes and Blackwell Pub. Asia Country of Publication: Japan NLM ID: 101520702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1124 (Electronic) Linking ISSN: 20401116 NLM ISO Abbreviation: J Diabetes Investig Subsets: MEDLINE
    • Publication Information:
      Original Publication: Tokyo : Asian Association for the Study of Diabetes and Blackwell Pub. Asia
    • Subject Terms:
      COVID-19*/prevention & control ; Glucose Intolerance* ; Diabetes Mellitus, Type 2*; Humans ; Glycated Hemoglobin/analysis ; Retrospective Studies ; Glycemic Control ; Blood Glucose/metabolism ; Japan/epidemiology ; Communicable Disease Control ; Body Composition ; Body Weight
    • Abstract:
      Aims/instruction: During the coronavirus disease 2019 (COVID-19) pandemic, the lockdowns in Europe raised concerns about negative effects on glycemic control and body composition in patients with diabetes. In Japan, voluntary-based restrictions were imposed as the declaration of a state of emergency (DSE), whose metabolic consequences have not been fully investigated. We carried out a single-center retrospective study to evaluate changes in glycemic control and body composition in outpatients with glucose intolerance after the DSE.
      Materials and Methods: We enrolled outpatients with glucose intolerance: (i) for whom longitudinal data about body composition were available; (ii) who participated in dietary follow up with nutritionists; and (iii) whose laboratory data included glycated hemoglobin (HbA1c) levels before and after the DSE.
      Results: Among 415 patients, we found no significant changes in HbA1c overall after the DSE. Bodyweight and fat mass increased significantly, whereas skeletal mass decreased significantly. HbA1c changes after the DSE were significantly correlated with changes in bodyweight and fat mass. In 128 patients whose HbA1c levels increased ≥0.3%, changes in bodyweight and fat mass were significantly larger than those in the other 287 patients. With regard to lifestyle changes, increased snacking was likely to worsen glycemic control (odds ratio 1.76, P = 0.036).
      Conclusions: COVID-19 restrictions in Japan had unfavorable metabolic consequences for patients with glucose intolerance, highlighted by increased bodyweight and body fat, and decreased skeletal muscle. In addition, lifestyle changes, such as increased snacking, might worsen glycemic control. Clinical attention and interventions are required to prevent such metabolic changes.
      (© 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
    • References:
      Andersen KG, Rambaut A, Lipkin WI, et al. The proximal origin of SARS-CoV-2. Nat Med 2020; 26: 450-452.
      Tanaka N, Hamamoto Y, Kurotobi Y, et al. Lifestyle changes as a result of COVID-19 containment measures: Bodyweight and glycemic control in patients with diabetes in the Japanese declaration of a state of emergency. J Diabetes Investig 2021; 12: 1718-1722.
      Ludwig L, Scheyer N, Remen T, et al. The impact of COVID-19 lockdown on metabolic control and access to healthcare in people with diabetes: The CONFI-DIAB cross-sectional study. Diabetes Ther 2021; 12: 2207-2221.
      Hartmann B, Tittel SR, Femerling M, et al. COVID-19 lockdown periods in 2020: Good maintenance of metabolic control in adults with type 1 and type 2 diabetes. Exp Clin Endocrinol Diabetes 2022. https://doi.org/10.1055/a-1743-2537. Epub ahead of print.
      Sutkowska E, Marciniak DM, Sutkowska K, et al. The impact of lockdown caused by the COVID-19 pandemic on glycemic control in patients with diabetes. Endocrine 2022; 76: 273-281.
      Makki I, Alnoon N, Rahmani N, et al. Impact of COVID 19 lockdown on glycemic control in patients with type 2 diabetes mellitus in Dubai. Curr Diabetes Rev 2021; 18: e081221198650.
      Dissanayake H, Soysa P, Samarathunga T, et al. Impact of COVID-19 lockdown on people living with diabetes: Experience from a low-middle income country in South Asia. Prim Care Diabetes 2022; 16: 127-134.
      Ojo O, Wang XH, Ojo OO, et al. The effects of COVID-19 lockdown on glycaemic control and lipid profile in patients with type 2 diabetes: A systematic review and meta-analysis. Int J Environ Res Public Health 2022; 19: 1095.
      Mano F, Ikeda K, Uchida Y, et al. Novel psychosocial factor involved in diabetes self-care in the Japanese cultural context. J Diabetes Investig 2019; 10: 1102-1107.
      Parady G, Taniguchi A, Takami K. Travel behavior changes during the COVID-19 pandemic in Japan: Analyzing the effects of risk perception and social influence on going-out self-restriction. Transp Res Interdiscip Perspect 2020; 7: 100649, 100181.
      Munekawa C, Hosomi Y, Hashimoto Y, et al. Effect of coronavirus disease 2019 pandemic on the lifestyle and glycemic control in patients with type 2 diabetes: A cross-section and retrospective cohort study. Endocr J 2021; 68: 201-210.
      Hosomi Y, Munekawa C, Hashimoto Y, et al. The effect of COVID-19 pandemic on the lifestyle and glycemic control in patients with type 1 diabetes: A retrospective cohort study. Diabetol Int 2021; 13: 1-6.
      Takahara M, Watanabe H, Shiraiwa T, et al. Lifestyle changes and their impact on glycemic control and weight control in patients with diabetes during the coronavirus disease 2019 pandemic in Japan. J Diabetes Investig 2022; 13: 375-385.
      Hasegawa Y, Takahashi F, Hashimoto Y, et al. Effect of COVID-19 pandemic on the change in skeletal muscle mass in older patients with type 2 diabetes: A retrospective cohort study. Int J Environ Res Public Health 2021; 18: 4188.
      Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus, Seino Y, Nanjo K, et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig 2010; 1: 212-228.
      Kaido T, Tamai Y, Hamaguchi Y, et al. Effects of pretransplant sarcopenia and sequential changes in sarcopenic parameters after living donor liver transplantation. Nutrition 2017; 33: 195-198.
      European Medicines Agency. Clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus. Available from: https://www.ema.europa.eu/en/clinical-investigation-medicinal-products-treatment-prevention-diabetes-mellitus Accessed April 1, 2022.
      Zechmann S, Hotz L, Di Gangi S, et al. Impact of SARS-CoV-2 lockdown on glycaemic control: A retrospective observational cohort study in a tertiary setting. J Clin Med 2021; 10: 4098-4112.
      Silverii GA, Delli Poggi C, Dicembrini I, et al. Glucose control in diabetes during home confinement for the first pandemic wave of COVID-19: A meta-analysis of observational studies. Acta Diabetol 2021; 58: 1603-1611.
      Biamonte E, Pegoraro F, Carrone F, et al. Weight change and glycemic control in type 2 diabetes patients during COVID-19 pandemic: The lockdown effect. Endocrine 2021; 72: 604-610.
      Biancalana E, Parolini F, Mengozzi A, et al. Short-term impact of COVID-19 lockdown on metabolic control of patients with well-controlled type 2 diabetes: A single-Centre observational study. Acta Diabetol 2021; 58: 431-436.
      Terakawa A, Bouchi R, Kodani N, et al. Living and working environments are important determinants of glycemic control in patients with diabetes during the COVID-19 pandemic: A retrospective observational study. J Diabetes Investig 2022; 13: 1094-1104.
      Tanji Y, Sawada S, Watanabe T, et al. Impact of COVID-19 pandemic on glycemic control among outpatients with type 2 diabetes in Japan: A hospital-based survey from a country without lockdown. Diabetes Res Clin Pract 2021; 176: 108840-108846.
      Maruo Y, Irie Y, Obata Y, et al. Medium-term influence of the coronavirus disease 2019 pandemic on patients with diabetes: A single-center cross-sectional study. Intern Med 2022; 61: 303-311.
      Hansel B, Potier L, Chalopin S, et al. The COVID-19 lockdown as an opportunity to change lifestyle and body weight in people with overweight/obesity and diabetes: Results from the national French COVIDIAB cohort. Nutr Metab Cardiovasc Dis 2021; 31: 2605-2611.
      Nonogaki K, Nozue K, Oka Y. Social isolation affects the development of obesity and type 2 diabetes in mice. Endocrinology 2007; 148: 4658-4666.
      Kirwan R, McCullough D, Butler T, et al. Sarcopenia during COVID-19 lockdown restrictions: Long-term health effects of short-term muscle loss. Geroscience 2020; 42: 1547-1578.
      Fukushima M, Suzuki H, Seino Y. Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes. Diabetes Res Clin Pract 2004; 66: S37-S43.
      Sone H, Ito H, Ohashi Y, et al. Obesity and type 2 diabetes in Japanese patients. Lancet 2003; 361: 85.
    • Contributed Indexing:
      Keywords: Body composition; COVID-19; Social restrictions
    • Accession Number:
      0 (Glycated Hemoglobin A)
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20220818 Date Completed: 20221206 Latest Revision: 20221207
    • Publication Date:
      20240628
    • Accession Number:
      PMC9538039
    • Accession Number:
      10.1111/jdi.13893
    • Accession Number:
      35980313