Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus.

Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE

Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers
Original Publication: Schiphol, The Netherlands : Bentham Science Publishers,

Diabetes Mellitus, Type 1* ; Diabetes Mellitus, Type 2*; Humans ; Small Ubiquitin-Related Modifier Proteins/genetics ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Protein Processing, Post-Translational

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to environmental factors, some epigenetic and post-translational modifications have critical roles in the pathogenesis of diabetes and its complications. Reversible covalent modification such as SUMOylation by SUMO (Small Ubiquitin-like Modifier) has emerged as a new mechanism that affects the dynamic regulation of proteins. In this review, we initially focus on the function of SUMO and SUMOylation. Subsequently, we assess the potential effects of this process in the pathogenesis of type 1 and 2 diabetes mellitus.
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Keywords: Diabetes mellitus; SUMO; SUMOylation; Small Ubiquitin-like modifier; epigenetic; hyperglycemia

0 (Small Ubiquitin-Related Modifier Proteins)

Date Created: 20220818 Date Completed: 20230316 Latest Revision: 20230316

20230320

10.2174/0929867329666220817142848

35980066