Consecutive reference intervals for biochemical indices related to serum lipid levels and renal function during normal pregnancy.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967799 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2393 (Electronic) Linking ISSN: 14712393 NLM ISO Abbreviation: BMC Pregnancy Childbirth Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Cholesterol* ; Lipids*; Adult ; Cholesterol, HDL ; Creatinine ; Female ; Humans ; Infant ; Infant, Newborn ; Kidney/physiology ; Pregnancy ; Triglycerides
    • Abstract:
      Background: Physiological changes that occur during pregnancy can influence serum lipid levels and laboratory tests for renal function. Therefore, we established consecutive and reliable RIs for serum lipid and renal function indices for pregnant women in China throughout the entirety of pregnancy.
      Methods: We included 120 healthy pregnant women who underwent a naturally conceived and uncomplicated pregnancy and delivered a healthy singleton neonate. Serum samples were collected at ten time points (pre-pregnancy, gestational age ≤ 8 weeks (W), 8 W +1 to 12 W, 12 W +1 to 16 W, 16 W +1 to 20 W, 20 W +1 to 24 W, 24 W +1 to 28 W, 28 W +1 to 32 W, 32 W +1 to 36 W, and 36 W +1 to 40 W) and analyzed for ten common serum lipid and renal function analytes. RIs were calculated according to the International Federation of Clinical Chemistry and Laboratory Medicine recommendations and compared with the established RIs for healthy adult women.
      Results: During pregnancy, we observed significant increases in total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein-A1 (Apo-A1), apolipoprotein-B (Apo-B), cystatin C (Cys-C), and estimated glomerular filtration rate (eGFR). We also observed clear reductions in urea, creatinine (Crea), and uric acid (UA). Compared with the previously established RIs, the most significant misclassifications were recorded for TG, Apo-A1, Crea, and eGFR.
      Conclusions: We successfully described key changes in serum lipid levels and renal function indices throughout pregnancy. It is important to establish RIs for blood indices in women undergoing normal pregnancies during different period of pregnancy to avoid the misdiagnosis of disease states.
      (© 2022. The Author(s).)
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    • Grant Information:
      2019ZD0764 Liaoning Province Natural Science Foundation Project; 2018YFE0207300 National Key Research and Development Program of China; 2019JH6/10400009 Liaoning Province Central Government's special project to guide local scientific and technological development
    • Contributed Indexing:
      Keywords: Biochemical indices; Pregnancy; Reference interval; Renal function; Serum lipid
    • Accession Number:
      0 (Cholesterol, HDL)
      0 (Lipids)
      0 (Triglycerides)
      97C5T2UQ7J (Cholesterol)
      AYI8EX34EU (Creatinine)
    • Publication Date:
      Date Created: 20220815 Date Completed: 20220817 Latest Revision: 20220819
    • Publication Date:
      20221213
    • Accession Number:
      PMC9377122
    • Accession Number:
      10.1186/s12884-022-04960-0
    • Accession Number:
      35971117