Marsupial satellite DNA as faithful reflections of long-terminal repeat retroelement structure.

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  • Additional Information
    • Source:
      Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 8704544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1480-3321 (Electronic) Linking ISSN: 08312796 NLM ISO Abbreviation: Genome Subsets: MEDLINE
    • Publication Information:
      Publication: 2011- : Ottawa, ON : Canadian Science Publishing
      Original Publication: Ottawa, Canada : National Research Council of Canada, c1987-
    • Subject Terms:
      Marsupialia*/genetics ; Retroelements*; Animals ; DNA, Satellite/genetics ; Mammals/genetics ; Terminal Repeat Sequences/genetics
    • Abstract:
      Long terminal repeat (LTR) retroelements, including endogenous retroviruses, are one of the origins of satellite DNAs. However, the vast majority of satellite DNAs originating from LTR retroelements consists of parts of the element. In addition, they frequently contain sequences unrelated to that element. Here we report a novel marsupial satellite DNA (named walbRep) that contains, and consists solely of, the entire sequence of an LTR retroelement (the walb element). As is common with LTR retroelements, walb copies exhibit length variation. We focused on the abundance of copies of a specific length (2.7 kb) in the genome of the red-necked wallaby. Cloning and analyses of long genomic DNA fragments revealed a satellite DNA in which the LTR sequence (0.4 kb) and the sequence of the internal region of a nonautonomous walb copy (2.3 kb) were repeated alternately. The junctions between these two components exhibited the same end-to-end arrangements as those in the walb element. This satellite organization could be accounted for by a simple formation model that includes slippage during chromosome pairing followed by homologous recombination but does not invoke any other types of rearrangements. We discuss the possible reasons why satellite DNAs having such structures are rarely found in mammals.
    • Contributed Indexing:
      Keywords: ADN répété; endogenous retrovirus; mammal; mammifère; repetitive DNA; retrotransposon; rétrotransposon; rétrovirus endogène; wallaby
    • Accession Number:
      0 (DNA, Satellite)
      0 (Retroelements)
    • Publication Date:
      Date Created: 20220805 Date Completed: 20220922 Latest Revision: 20220922
    • Publication Date:
      20221213
    • Accession Number:
      10.1139/gen-2022-0039
    • Accession Number:
      35930809