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Viral-host interactions during splicing and nuclear export of influenza virus mRNAs.
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- Author(s): Esparza M;Esparza M; Bhat P; Bhat P; Fontoura BM; Fontoura BM
- Source:
Current opinion in virology [Curr Opin Virol] 2022 Aug; Vol. 55, pp. 101254. Date of Electronic Publication: 2022 Jul 29.
- Publication Type:
Journal Article; Review; Research Support, N.I.H., Extramural
- Language:
English
- Additional Information
- Source:
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101560941 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-6265 (Electronic) Linking ISSN: 18796257 NLM ISO Abbreviation: Curr Opin Virol Subsets: MEDLINE
- Publication Information:
Original Publication: Amsterdam : Elsevier
- Subject Terms:
- Abstract:
As influenza-A viruses (IAV) replicate in the host cell nucleus, intranuclear pathways are usurped for viral gene expression. The eight genomic viral ribonucleoproteins (vRNPs) segments of IAV are transcribed and two generate viral mRNAs (M and NS) that undergo alternative splicing followed by export from the nucleus. The focus of this review is on viral RNA splicing and nuclear export. Recent mechanistic advances on M and NS splicing show differential regulation by RNA-binding proteins as well as distinct intranuclear localization. After a review of IAV splicing, we will discuss the nuclear export of viral mRNAs, which occur by interacting with specific constituents of the host mRNA export machinery that translocate viral mRNAs through the nuclear pore complex for translation in the cytoplasm.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
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- Grant Information:
R01 AI125524 United States AI NIAID NIH HHS; R01 AI154635 United States AI NIAID NIH HHS
- Accession Number:
0 (RNA, Messenger)
0 (RNA, Viral)
- Publication Date:
Date Created: 20220731 Date Completed: 20220913 Latest Revision: 20230223
- Publication Date:
20230223
- Accession Number:
PMC9945342
- Accession Number:
10.1016/j.coviro.2022.101254
- Accession Number:
35908311
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