Phytochemical analysis of Clinopodium candidissimum (Munby) Kuntze growing in Algeria by an integrated HS-SPME-GC-MS, NMR and HPLC-DAD-MS n approach: valorisation of an endemic natural source of bioactive compounds.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
    • Subject Terms:
      Solid Phase Microextraction*/methods ; Lamiaceae*/chemistry; Gas Chromatography-Mass Spectrometry ; Chromatography, High Pressure Liquid ; Algeria ; Phytochemicals/analysis
    • Abstract:
      Clinopodium candidissimum (Munby) Kuntze (Lamiaceae) is used in traditional medicine and as a food condiment in Algeria, where it is known as Zaater cheleuh and Nabta elbida. Here, we report the comprehensive characterisation of non-volatile polar constituents extracted from C. candidissimum aerial parts (a mixture of inflorescences, stems and leaves), and their aroma profile. Qualitative 1 H-NMR and quali-quantitative HPLC-MS n analyses of fractions obtained with solvents at different polarity revealed the presence of aglyconic and glycosylated flavonoids (3.1%), phenylpropanoids (3.6%), gallic acid derivatives (0.76%), and triterpenoids (0.62%), among the others. On the other hand, HS-SPME-GC-MS allowed to identify 38 volatile constituents, among which the oxygenated monoterpenes pulegone (44.8%), piperitenone (6.6%), isopulegone (5.8%) and neo-menthol (3.8%), and the sesquiterpene hydrocarbons germacrene D (16.2%) and bicyclogermacrene (3.0%) were the most abundant. Overall, results indicate that C. candidissimum represents an endemic natural source of antioxidants and bioactive compounds, and they will be useful for further studies on this species.
    • Contributed Indexing:
      Keywords: Clinopodium candidissimum (Munby) Kuntze; HPLC-DAD-MSn; HS-SPME-GC-MS; NMR; phytoconstituents; secondary metabolites
    • Accession Number:
      0 (Phytochemicals)
    • Publication Date:
      Date Created: 20220727 Date Completed: 20231216 Latest Revision: 20231216
    • Publication Date:
      20231217
    • Accession Number:
      10.1080/14786419.2022.2104272
    • Accession Number:
      35895051