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Are we there yet? Increasing use of cardioprotective antihyperglycemic agents in patients with T2D and CVD or CV risk in the United States.
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- Author(s): Mody R;Mody R; Meyers J; Meyers J; Yu M; Yu M; Davis K; Davis K; Levine JA; Levine JA
- Source:
Current medical research and opinion [Curr Med Res Opin] 2022 Nov; Vol. 38 (11), pp. 1785-1795. Date of Electronic Publication: 2022 Jun 27.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Informa Healthcare Country of Publication: England NLM ID: 0351014 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-4877 (Electronic) Linking ISSN: 03007995 NLM ISO Abbreviation: Curr Med Res Opin Subsets: MEDLINE
- Publication Information: Publication: 1995- : Newbury, Berkshire, U.K. : Informa Healthcare
Original Publication: London, M. D. Promotions, ltd. - Subject Terms: Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/drug therapy ; Diabetes Mellitus, Type 2*/epidemiology ; Cardiovascular Diseases*/epidemiology ; Cardiovascular Diseases*/prevention & control ; Cardiovascular Diseases*/diagnosis; Humans ; United States/epidemiology ; Hypoglycemic Agents/adverse effects ; Cardiotonic Agents/therapeutic use ; Risk Factors ; Heart Disease Risk Factors ; Glucagon-Like Peptide 1/therapeutic use ; Glucagon-Like Peptide-1 Receptor/agonists
- Abstract: Objective: To report on the use of antihyperglycemic agents (AHAs) by age (i.e. <65, ≥65 years) in patients with type 2 diabetes (T2D) and cardiovascular disease (CVD) or cardiovascular risk (CV risk) factors in the United States.
Methods: Patients with T2D and CVD (CVD cohort) or T2D and an additional CV risk factor without pre-existing CVD (CV risk cohort) were identified from 2015 to 2019 in a claims database. Patients were followed from their first observed CVD diagnosis or CV risk factor for each year they were continuously enrolled or until occurrence of a CVD diagnosis (CV risk cohort only). Classes of AHAs received were reported by year, cohort, and age group.
Results: From 2015 to 2019, the percentage of patients <65 years on glucagon-like peptide-1 receptor agonists (GLP-1 RAs) increased (CVD: 9-17%, CV risk: 9-17%) and was approximately twice that of those ≥65 years (CVD: 4-8%, CV risk: 4-8%); the percentage of patients <65 years on sodium-glucose cotransporter-2 (SGLT2) inhibitors increased (CVD: 11-16%, CV risk: 11-17%) and was approximately triple that of those ≥65 years (CVD: 3-6%, CV risk: 4-7%).
Conclusions: The use of GLP-1 RAs and SGLT2 inhibitors increased during the study period; however, most patients did not receive these medications. Patients aged ≥65 years were particularly disadvantaged. - Contributed Indexing: Keywords: Type 2 diabetes; antihyperglycemic treatment; cardiovascular disease; cardiovascular risk; glucagon-like peptide-1 receptor agonists; sodium-glucose cotransporter-2 inhibitors; treatment patterns
- Accession Number: 0 (Hypoglycemic Agents)
0 (Cardiotonic Agents)
89750-14-1 (Glucagon-Like Peptide 1)
0 (Glucagon-Like Peptide-1 Receptor) - Publication Date: Date Created: 20220627 Date Completed: 20221121 Latest Revision: 20221226
- Publication Date: 20231215
- Accession Number: 10.1080/03007995.2022.2085962
- Accession Number: 35758147
- Source:
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