Associations of organophosphate metabolites with thyroid hormone and antibody levels: findings from U.S. National Health and Nutrition Examination Survey (NHANES).

Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE

Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed

Organophosphates* ; Insecticides*; Male ; Female ; Animals ; Humans ; Nutrition Surveys ; Creatinine ; Thyroid Hormones ; Thyrotropin ; Phosphates

Studies have shown that organophosphate pesticides (OPs) exposure may disrupt thyroid endocrine functions in animal models, agricultural population, occupational workers, and work-related population. However, the relationships between OPs exposure and thyroid hormone levels in the general population are unclear. This study aimed to explore the relationships of OPs exposure with thyroid hormone and antibody levels in the general population. We analyzed a sample of 1089 US adults from the National Health and Nutrition Examination Survey (NHANES) 2001-2002. OPs exposure was estimated using measures of six non-specific dialkyl phosphate metabolites (DAPs), e.g., dimethylphosphate (DMP). Multiple linear regression models were used to examine the associations of OPs exposure with thyroid hormone and antibody levels. The medians of urinary ∑DAPs detected in males and females were 32.98 nmol/g creatinine and 40.77 nmol/g creatinine, with statistical significance (p = 0.001). After controlling for sociodemographic factors, we found that concentrations of urinary OPs metabolites were positively associated with the serum thyroid stimulating hormone (TSH) in the general US population, particularly in males; OPs metabolites were associated with the serum TgAb, tT3, fT3, and TSH. These findings showed that thyroid hormone and antibody disruption are probably associated with OPs exposure in the general population; more studies are needed to confirm our findings.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

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ZFY2001001 Major Progressive Project of the Beijing Institute of Occupational Disease Prevention and Treatment President's Fund; BJAST-RD-BMILP202103&08 the Young Talents Project of Beijing Municipal Institute of Labour Protection

Keywords: Dialkyl phosphate metabolites (DAPs); NHANES; Organophosphate pesticides (OPs); Thyroid antibody; Thyroid hormone

0 (Organophosphates)
AYI8EX34EU (Creatinine)
0 (Thyroid Hormones)
9002-71-5 (Thyrotropin)
0 (Insecticides)
0 (Phosphates)

Date Created: 20220617 Date Completed: 20221026 Latest Revision: 20221026

20231215

10.1007/s11356-022-21385-6

35713824