Widely cited publications of Michael Bárány in 1964 and 1967 as tipping points in understanding myosin molecular motors.

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  • Author(s): Solaro RJ;Solaro RJ
  • Source:
    Archives of biochemistry and biophysics [Arch Biochem Biophys] 2022 Sep 30; Vol. 727, pp. 109319. Date of Electronic Publication: 2022 Jun 14.
  • Publication Type:
    Journal Article; Review; Research Support, N.I.H., Extramural
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE
    • Publication Information:
      Publication: <2000- > : San Diego, CA : Elsevier
      Original Publication: New York, NY : Academic Press
    • Subject Terms:
      Myosins*/chemistry ; Sarcomeres*; Biochemistry ; Biophysics
    • Abstract:
      In 1964 Michael Bárány and colleagues published a paper ((M. Bárány, E. Gaetjens, K. Bárány, Karp E. Arch Biochem Biophys 106(1964)280-93. http://10.1016/0003-9861(64)90,189-4)) that has been one of the most cited papers in Archives of Biochemistry and Biophysics. This was followed in 1967 by another most cited paper (M. Bárány. J Gen Physiol 50(1967)197-218. https://doi.org/10.1085/jgp.50.6.197). I have commemorated these achievements as tipping points in the understanding of myosin motors in muscle function. Tipping points are generally defined as a temporal point in which a series of progressive advances (in this case the understanding of the relations between myosin ATP hydrolysis and muscle function) inspire more expansive, wide-ranging, significant changes. I first concisely summarize the background against which the papers came to publication as well as the unimaginable personal challenges faced by Michael and Kate Bárány. A final section summarizes the impact of these publications as key steps in the progression of contemporary understanding of diverse control of myosin ATPase activity with focus on the thick filaments in cardiac homeostasis, disorders, and as targets for therapeutic applications in translational investigations.
      (Copyright © 2022 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Heart muscle; Myosin ATPase; Skeletal muscle; Velocity of shortening
    • Accession Number:
      EC 3.6.4.1 (Myosins)
    • Publication Date:
      Date Created: 20220616 Date Completed: 20220726 Latest Revision: 20220808
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.abb.2022.109319
    • Accession Number:
      35709967