Immunomodulatory strategies for bone regeneration: A review from the perspective of disease types.

Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

Publication: <1995-> : Amsterdam : Elsevier Science
Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980-

Bone Regeneration* ; Osteogenesis*; Biocompatible Materials/therapeutic use ; Immunomodulation ; Tissue Engineering

Tissue engineering strategies for treating bone loss to date have largely focused on targeting stem cells or vascularization. Immune cells, including macrophages and T cells, can also indirectly enhance bone healing via cytokine secretion to interact with other bone niche cells. Bone niche cues and local immune environment vary depending on anatomical location, size of defects and disease types. As such, it is critical to evaluate the role of the immune system in the context of specific bone niche and different disease types. This review focuses on immunomodulation research for bone applications using biomaterials and cell-based strategies, with a unique perspective from different disease types. We first reviewed applications for prolonging orthopaedic implant lifetime and enhancing fracture healing, two clinical challenges where immunomodulatory strategies were initially developed for orthopedic applications. We then reviewed recent research progress in harnessing immunomodulatory strategies for regenerating critical-sized, long bone or cranial bone defects, and treating osteolytic bone diseases. Remaining gaps in knowledge, future directions and opportunities were also discussed.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)

Nano Lett. 2019 May 8;19(5):3040-3048. (PMID: 30968694)
Autoimmun Rev. 2019 Nov;18(11):102397. (PMID: 31520798)
Int J Nanomedicine. 2020 Sep 29;15:7185-7198. (PMID: 33061375)
Oral Dis. 2019 Nov;25(8):1866-1878. (PMID: 30565778)
J Periodontal Res. 2019 Jun;54(3):207-217. (PMID: 30474205)
Acta Biomater. 2020 Apr 1;106:22-33. (PMID: 31926336)
J Clin Periodontol. 2015 May;42(5):448-57. (PMID: 25875208)
Biomaterials. 2016 Dec;111:163-178. (PMID: 27728815)
EMBO Mol Med. 2015 Mar 14;7(5):547-61. (PMID: 25770819)
Acta Biomater. 2016 Sep 1;41:273-81. (PMID: 27260104)
Acta Biomater. 2017 Oct 15;62:362-371. (PMID: 28867647)
Int J Nanomedicine. 2019 Feb 08;14:1069-1084. (PMID: 30804671)
ACS Appl Mater Interfaces. 2018 Jan 24;10(3):2377-2390. (PMID: 29280610)
ACS Appl Mater Interfaces. 2019 Nov 20;11(46):43689-43697. (PMID: 31660718)
Biomaterials. 2017 Feb;117:1-9. (PMID: 27918885)
Tissue Eng Part B Rev. 2015 Aug;21(4):354-64. (PMID: 25742724)
Acta Biomater. 2016 Sep 15;42:378-388. (PMID: 27318268)
Front Immunol. 2019 Aug 16;10:1954. (PMID: 31475013)
Autoimmun Rev. 2011 May;10(7):410-5. (PMID: 21256250)
Adv Funct Mater. 2020 Sep 10;30(37):. (PMID: 32952493)
ACS Nano. 2019 Jun 25;13(6):6581-6595. (PMID: 31125522)
Nano Res. 2018;11(10):5573-5583. (PMID: 31656553)
J Bone Miner Res. 2015 Dec;30(12):2140-9. (PMID: 26531055)
Stem Cells Int. 2018 Jul 5;2018:7089484. (PMID: 30123292)
J Tissue Eng Regen Med. 2014 Nov;8(11):841-9. (PMID: 22782939)
Nat Rev Immunol. 2017 Jan;17(1):60-75. (PMID: 27916980)
Artif Cells Nanomed Biotechnol. 2018 Nov;46(7):1425-1435. (PMID: 28853299)
Biomaterials. 2019 Mar;196:51-66. (PMID: 29107337)
Nat Med. 2011 Nov 20;17(12):1594-601. (PMID: 22101767)
Int Orthop. 2016 Jul;40(7):1545-52. (PMID: 26498175)
Acta Biomater. 2018 Sep 1;77:106-115. (PMID: 29981946)
Sci Transl Med. 2013 Mar 20;5(177):177ra36. (PMID: 23515078)
Front Immunol. 2019 Apr 02;10:663. (PMID: 31001270)
Acta Biomater. 2019 Apr 1;88:162-180. (PMID: 30735811)
Nat Commun. 2016 Mar 22;7:11051. (PMID: 27001940)
Biomaterials. 2020 May;239:119833. (PMID: 32062479)
Bonekey Rep. 2013 Jun 26;2:373. (PMID: 25035807)
Acta Biomater. 2014 Nov;10(11):4730-4741. (PMID: 25058402)
BMB Rep. 2008 Jul 31;41(7):495-510. (PMID: 18682033)
J Clin Invest. 2013 Feb;123(2):866-73. (PMID: 23321670)
Acta Biomater. 2019 May;90:393-402. (PMID: 30965142)
J Tissue Eng Regen Med. 2014 Feb;8(2):120-30. (PMID: 22495762)
Biomaterials. 2010 Dec;31(35):9232-43. (PMID: 20863559)
Biomaterials. 2011 Jan;32(2):366-73. (PMID: 20880582)
Stem Cell Res Ther. 2020 Aug 8;11(1):345. (PMID: 32771052)
Cell Death Dis. 2020 Jun 2;11(6):414. (PMID: 32488049)
Biomed Res Int. 2019 Aug 4;2019:1983131. (PMID: 31467871)
Sci Adv. 2021 May 12;7(20):. (PMID: 33980490)
J Orthop Surg (Hong Kong). 2018 May-Aug;26(3):2309499018802487. (PMID: 30270749)
Nanomaterials (Basel). 2021 Feb 19;11(2):. (PMID: 33669621)
Stem Cell Res Ther. 2019 Dec 5;10(1):375. (PMID: 31805984)
Stem Cell Res Ther. 2018 Apr 11;9(1):100. (PMID: 29642953)
Int J Mol Sci. 2016 May 19;17(5):. (PMID: 27213355)
Nat Mater. 2021 Apr;20(4):560-569. (PMID: 33168979)
Biomaterials. 2014 Jan;35(1):214-24. (PMID: 24125774)
Cell Prolif. 2022 Jan;55(1):e13172. (PMID: 34953003)
ACS Appl Mater Interfaces. 2018 Aug 1;10(30):25547-25560. (PMID: 30001112)
Cell Death Dis. 2016 Jan 21;7:e2062. (PMID: 26794657)
Biomaterials. 2017 Jul;131:15-26. (PMID: 28371624)
Curr Osteoporos Rep. 2018 Apr;16(2):138-145. (PMID: 29508143)
EBioMedicine. 2019 May;43:620-631. (PMID: 31076346)
Tissue Eng Part A. 2011 Jan;17(1-2):127-37. (PMID: 20695777)
Nat Med. 2014 Nov;20(11):1270-8. (PMID: 25282358)
Curr Osteoporos Rep. 2016 Oct;14(5):239-47. (PMID: 27542011)
Tissue Eng Part A. 2018 Sep;24(17-18):1341-1353. (PMID: 29652608)
Stem Cell Res Ther. 2017 Dec 06;8(1):277. (PMID: 29212557)
Front Immunol. 2018 Dec 18;9:2963. (PMID: 30619321)
J Craniofac Surg. 2019 Nov-Dec;30(8):2640-2645. (PMID: 31609958)
J Tissue Eng Regen Med. 2019 Aug;13(8):1466-1481. (PMID: 31132812)
Int J Pharm. 2018 Apr 5;540(1-2):57-64. (PMID: 29408684)
Nat Commun. 2018 Oct 16;9(1):4291. (PMID: 30327464)
Acta Biomater. 2019 Apr 15;89:242-251. (PMID: 30880234)
Nat Mater. 2015 Jun;14(6):643-51. (PMID: 25985456)
J Control Release. 2016 May 28;230:64-72. (PMID: 27057749)
ACS Appl Mater Interfaces. 2019 Nov 6;11(44):41758-41769. (PMID: 31610117)
Mol Cell Biochem. 2012 Jan;359(1-2):399-407. (PMID: 21874315)
J Bone Miner Res. 2016 Oct;31(10):1899-1908. (PMID: 27161765)
Adv Drug Deliv Rev. 2018 Apr;129:285-294. (PMID: 29357301)
Acta Biomater. 2017 Feb;49:296-305. (PMID: 27856281)
Adv Healthc Mater. 2017 Nov;6(21):. (PMID: 28758712)
J Bone Miner Res. 2015 Mar;30(3):412-22. (PMID: 25264308)
PLoS One. 2012;7(10):e46945. (PMID: 23071670)
Stem Cell Res Ther. 2019 Nov 15;10(1):320. (PMID: 31730019)
Biomaterials. 2019 Jul;209:1-9. (PMID: 31022556)
Acta Biomater. 2017 Oct 1;61:217-232. (PMID: 28807800)
ACS Nano. 2018 Oct 23;12(10):9785-9799. (PMID: 30141906)
Mol Med. 2018 May 9;24(1):20. (PMID: 30134793)
J Control Release. 2015 Oct 28;216:140-8. (PMID: 26282098)
Biomaterials. 2013 Dec;34(38):9853-62. (PMID: 24064148)
J Mater Chem B. 2020 May 14;8(18):4067-4079. (PMID: 32242565)
Tissue Eng Part A. 2020 Aug;26(15-16):852-862. (PMID: 32046626)
Biomaterials. 2020 Jan;227:119552. (PMID: 31670079)
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12938-43. (PMID: 22837404)
Histochem Cell Biol. 2018 Apr;149(4):393-404. (PMID: 29435765)
Front Immunol. 2018 Apr 05;9:657. (PMID: 29675022)
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18525-30. (PMID: 24167272)
Stem Cells Int. 2018 Jun 14;2018:3057624. (PMID: 30013600)
Autoimmun Rev. 2017 Feb;16(2):103-113. (PMID: 27988432)
Biomaterials. 2019 Feb;192:405-415. (PMID: 30500722)
Biomaterials. 2013 Dec;34(38):10287-95. (PMID: 24075408)
Biomaterials. 2010 Nov;31(31):7960-70. (PMID: 20688388)
Nat Rev Immunol. 2015 Jan;15(1):30-44. (PMID: 25534621)
Bone. 2016 Mar;84:93-103. (PMID: 26723577)
Biomaterials. 2018 Apr;161:216-227. (PMID: 29421557)
Adv Healthc Mater. 2019 May;8(10):e1801433. (PMID: 30938094)
Adv Funct Mater. 2015 Apr 15;25(15):2296-2307. (PMID: 26120294)
Biomed Mater. 2018 Apr 25;13(4):044105. (PMID: 29359704)
Cell Death Differ. 2016 Dec;23(12):1941-1951. (PMID: 27472064)
Tissue Eng Part A. 2019 Jan;25(1-2):34-43. (PMID: 29652606)
J Tissue Eng Regen Med. 2016 Apr;10(4):305-14. (PMID: 23653421)
J Tissue Eng Regen Med. 2018 Mar;12(3):e1796-e1812. (PMID: 29049870)
Acta Biomater. 2019 Sep 15;96:605-618. (PMID: 31269454)
Regen Biomater. 2019 Jun;6(3):163-174. (PMID: 31198584)
J Bone Miner Res. 2011 Jan;26(1):113-24. (PMID: 20641004)
Sci Transl Med. 2017 Apr 19;9(386):. (PMID: 28424334)
Cytometry A. 2020 May;97(5):496-503. (PMID: 31758756)
Front Bioeng Biotechnol. 2018 Feb 12;6:5. (PMID: 29484293)
J Periodontal Res. 2017 Feb;52(1):135-146. (PMID: 27021598)
Front Immunol. 2019 Apr 16;10:798. (PMID: 31040848)
Nano Lett. 2019 Jan 9;19(1):124-134. (PMID: 30521345)
J Dent Res. 2014 Nov;93(11):1124-32. (PMID: 25252877)
Sci Rep. 2016 Feb 11;6:20909. (PMID: 26864916)
Science. 2016 Apr 15;352(6283):366-70. (PMID: 27081073)
Sci Adv. 2020 Apr 29;6(18):eaaz6579. (PMID: 32494680)
Biomacromolecules. 2016 Nov 14;17(11):3706-3713. (PMID: 27741396)
Tissue Eng Part A. 2017 May;23(9-10):367-377. (PMID: 28027709)
Curr Opin Rheumatol. 2017 Mar;29(2):201-207. (PMID: 27941390)
J Biomed Mater Res A. 2018 Jun;106(6):1626-1633. (PMID: 29453815)
Adv Drug Deliv Rev. 2019 Sep - Oct;149-150:85-94. (PMID: 31103451)
EBioMedicine. 2018 Mar;29:60-69. (PMID: 29449195)
Biomed Res Int. 2016;2016:1946585. (PMID: 27725934)
Bone Res. 2018 Oct 22;6:31. (PMID: 30374416)
Biomaterials. 2020 Jan;227:119548. (PMID: 31670033)
Front Immunol. 2019 Apr 05;10:713. (PMID: 31024548)
J Mater Chem B. 2019 Sep 18;7(36):5541-5553. (PMID: 31451811)
Eur Cell Mater. 2018 Mar 6;35:165-177. (PMID: 29509226)
Nat Rev Rheumatol. 2016 Apr;12(4):243-9. (PMID: 26729461)
Stem Cells. 2012 Apr;30(4):762-72. (PMID: 22267310)
Tissue Eng Part A. 2018 Aug;24(15-16):1167-1178. (PMID: 29376477)
Front Immunol. 2018 Mar 23;9:585. (PMID: 29662491)
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20764-9. (PMID: 19075223)
Cell Tissue Res. 2012 Mar;347(3):567-73. (PMID: 21789579)
Clin Exp Pharmacol Physiol. 2018 May;45(5):430-436. (PMID: 29215756)
J Cell Biochem. 2003 Apr 1;88(5):873-84. (PMID: 12616527)
Arch Orthop Trauma Surg. 2011 Feb;131(2):275-81. (PMID: 20730440)
Adv Healthc Mater. 2018 Mar;7(5):. (PMID: 29266807)
Biomaterials. 2016 Mar;83:127-41. (PMID: 26773669)
Front Immunol. 2019 Jun 19;10:1408. (PMID: 31275328)
Aging Cell. 2020 Mar;19(3):e13112. (PMID: 32096907)
Acta Biomater. 2016 Mar 01;32:298-308. (PMID: 26689470)
Bone. 2018 Jan;106:78-89. (PMID: 26529389)
Colloids Surf B Biointerfaces. 2017 Aug 1;156:270-281. (PMID: 28544959)
Stem Cell Res Ther. 2015 Oct 31;6:210. (PMID: 26519141)
Mater Sci Eng C Mater Biol Appl. 2019 Feb 1;95:355-362. (PMID: 30573259)
Biomaterials. 2017 Jan;113:203-216. (PMID: 27821306)
Stem Cells Int. 2018 Sep 9;2018:7168231. (PMID: 30271438)
Tissue Eng Part A. 2019 Aug;25(15-16):1096-1103. (PMID: 30652628)
Nat Commun. 2018 Apr 3;9(1):1275. (PMID: 29615615)
Sci Rep. 2017 Jul 6;7(1):4776. (PMID: 28684770)
J Biomed Mater Res B Appl Biomater. 2022 Feb;110(2):265-288. (PMID: 34318595)
J Leukoc Biol. 2019 Mar;105(3):473-487. (PMID: 30452781)
J Periodontal Res. 2019 Aug;54(4):329-338. (PMID: 30635919)
Biomaterials. 2020 Feb;230:119642. (PMID: 31787332)
Biomaterials. 2015 Jan;37:194-207. (PMID: 25453950)
J Tissue Eng Regen Med. 2017 Jul;11(7):1974-1985. (PMID: 26549303)
Biomark Res. 2019 Mar 18;7:6. (PMID: 30923617)
Front Immunol. 2017 May 24;8:562. (PMID: 28596766)
Biomaterials. 2019 Jun;206:115-132. (PMID: 30933774)
Biomaterials. 2017 Nov;144:176-187. (PMID: 28837959)
Bioact Mater. 2020 Sep 21;6(3):666-683. (PMID: 33005830)
Adv Sci (Weinh). 2018 Aug 07;5(10):1800749. (PMID: 30356934)
Bone Res. 2018 Apr 27;6:15. (PMID: 29736302)
Periodontol 2000. 2017 Oct;75(1):7-23. (PMID: 28758294)
Tissue Eng Part A. 2015 Feb;21(3-4):498-509. (PMID: 25159486)
J Biomed Mater Res A. 2017 Apr;105(4):1175-1183. (PMID: 27998017)
Bone Res. 2019 Aug 15;7:25. (PMID: 31646015)
Bone. 2014 Jul;64:155-65. (PMID: 24721700)
Biomed Mater. 2017 Jul 04;12(4):045006. (PMID: 28378706)
Acta Biomater. 2018 Aug;76:344-358. (PMID: 29908975)
Acta Biomater. 2016 Feb;31:425-434. (PMID: 26675126)
Biomaterials. 2012 Jan;33(1):304-16. (PMID: 22019155)
Nat Nanotechnol. 2018 Dec;13(12):1182-1190. (PMID: 30177807)
Connect Tissue Res. 2011 Apr;52(2):109-18. (PMID: 20701464)
Mediators Inflamm. 2018 Apr 2;2018:7806912. (PMID: 29805313)
Acta Biomater. 2013 Feb;9(2):4956-63. (PMID: 23036944)
Acta Biomater. 2019 Apr 15;89:343-358. (PMID: 30853609)
Calcif Tissue Int. 2018 May;102(5):533-546. (PMID: 29204672)
Sci Rep. 2017 Sep 14;7(1):11549. (PMID: 28912509)
J Control Release. 2015 Dec 10;219:155-166. (PMID: 26264833)
Iran J Immunol. 2017 Mar;14(1):13-23. (PMID: 28341815)
Biomater Res. 2020 Feb 4;24:7. (PMID: 32042442)
Front Bioeng Biotechnol. 2018 Jul 13;6:98. (PMID: 30057898)
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110508. (PMID: 32228925)
Theranostics. 2018 Oct 29;8(19):5482-5500. (PMID: 30555559)
J Biomed Mater Res A. 2018 Oct;106(10):2744-2752. (PMID: 30084534)
Nat Mater. 2018 Dec;17(12):1134-1144. (PMID: 30349032)
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:330-340. (PMID: 31029326)
Cells. 2021 Aug 07;10(8):. (PMID: 34440785)
Basic Res Cardiol. 2019 Aug 1;114(5):34. (PMID: 31372765)
Biomaterials. 2017 Apr;122:10-22. (PMID: 28107661)
Stem Cell Res Ther. 2019 Jan 11;10(1):18. (PMID: 30635041)
Angew Chem Int Ed Engl. 2019 Mar 22;58(13):4254-4258. (PMID: 30724436)
J Bone Miner Res. 2011 Jul;26(7):1517-32. (PMID: 21305607)
Am J Pathol. 2014 Dec;184(12):3192-204. (PMID: 25285719)
Front Oral Biol. 2016;18:9-16. (PMID: 26599113)
J Biomed Mater Res A. 2012 Sep;100(9):2450-61. (PMID: 22566212)
J Control Release. 2017 Aug 10;259:92-104. (PMID: 28189629)
Theranostics. 2020 Jan 1;10(2):725-740. (PMID: 31903147)
Front Immunol. 2019 Oct 18;10:2443. (PMID: 31681320)

R01 AR074502 United States AR NIAMS NIH HHS; R01 DE024772 United States DE NIDCR NIH HHS

Keywords: Biomaterials; Bone regeneration; Diseases; Immunomodulation

0 (Biocompatible Materials)

Date Created: 20220606 Date Completed: 20220614 Latest Revision: 20230703

20230703

PMC9881498

10.1016/j.biomaterials.2022.121604

35667249