Gestational age, birth weight, and perinatal complications in mothers with diabetes and impaired glucose tolerance: Japan Environment and Children's Study cohort.

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  • Additional Information
    • Corporate Authors:
      Japan Environment and Children’s Study Group
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Diabetes Mellitus, Type 1*/complications ; Diabetes Mellitus, Type 2*/complications ; Diabetes Mellitus, Type 2*/epidemiology ; Diabetes, Gestational* ; Glucose Intolerance*/complications ; Glucose Intolerance*/epidemiology ; Hypertension, Pregnancy-Induced* ; Premature Birth*/epidemiology; Birth Weight ; Blood Glucose/analysis ; Child ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Japan/epidemiology ; Placenta/chemistry ; Pregnancy
    • Abstract:
      We aimed to determine the risk of perinatal complications during delivery in mothers with non-normal glucose tolerance in a large Japanese birth cohort. We analysed data of 24,295 neonate-mother pairs in the Japan Environment and Children's Study cohort between 2011 and 2014. We included 67 mothers with type 1 diabetes, 102 with type 2 diabetes (determined by questionnaire), 2,045 with gestational diabetes (determined by diagnosis), and 2,949 with plasma glucose levels ≥140 mg/dL (shown by a screening test for gestational diabetes). Gestational age, birth weight, placental weight, and proportions of preterm birth, and labour and neonatal complications at delivery in mothers with diabetes were compared with those in mothers with normal glucose tolerance. Mean gestational age was shorter in mothers with any type of diabetes than in mothers without diabetes. Birth weight tended to be heavier in mothers with type 1 diabetes, and placental weight was significantly heavier in mothers with type 1 and gestational diabetes and elevated plasma glucose levels (all p<0.05). The relative risks of any labour complication and any neonatal complication were 1.49 and 2.28 in type 2 diabetes, 1.59 and 1.95 in gestational diabetes, and 1.22 and 1.30 in a positive screening test result (all p<0.05). The relative risks of preterm birth, gestational hypertension, and neonatal jaundice were significantly higher in mothers with types 1 (2.77; 4.07; 2.04) and 2 diabetes (2.65; 5.84; 1.99) and a positive screening test result (1.29; 1.63; 1.12) than in those without diabetes (all p<0.05). In conclusion, placental weight is heavier in mothers with non-normal glucose tolerance. Preterm birth, gestational hypertension, and jaundice are more frequent in mothers with types 1 and 2 diabetes. A positive result in a screening test for gestational diabetes suggests not only a non-normal glucose tolerance, but also a medium (middle-level) risk of perinatal complications.
      Competing Interests: The authors have declared that no competing interests exist.
    • References:
      Placenta. 1997 Mar-Apr;18(2-3):227-30. (PMID: 9089786)
      PLoS One. 2015 Jul 24;10(7):e0133872. (PMID: 26207737)
      Diabetes Care. 2020 Dec;43(12):2983-2990. (PMID: 33087319)
      Int J Mol Sci. 2014 Sep 12;15(9):16153-85. (PMID: 25222554)
      Int J Obes (Lond). 2021 Dec;45(12):2666-2674. (PMID: 34465856)
      Microcirculation. 2014 Jan;21(1):15-25. (PMID: 23981199)
      Diabetologia. 1971 Dec;7(6):434-44. (PMID: 4111432)
      Am J Obstet Gynecol. 2004 Sep;191(3):964-8. (PMID: 15467573)
      Diabetes Res Clin Pract. 2003 Oct;62(1):47-53. (PMID: 14581157)
      Curr Diab Rep. 2015 Feb;15(2):569. (PMID: 25620402)
      Diabetes. 2009 Feb;58(2):453-9. (PMID: 19011170)
      N Engl J Med. 2008 May 8;358(19):1991-2002. (PMID: 18463375)
      J Clin Endocrinol Metab. 2013 Sep;98(9):E1438-47. (PMID: 23824413)
      Eur J Endocrinol. 2009 Apr;160(4):567-78. (PMID: 19179458)
      Diabetes Res Clin Pract. 2014 Jan;103(1):20-5. (PMID: 24405981)
      J Clin Endocrinol Metab. 2009 Nov;94(11):4284-91. (PMID: 19808847)
      BMJ. 2004 Apr 17;328(7445):915. (PMID: 15066886)
      BMC Pregnancy Childbirth. 2017 Oct 10;17(1):349. (PMID: 29017467)
      Endocr J. 2014;61(8):759-64. (PMID: 24838051)
      BMJ. 2006 Jul 22;333(7560):177. (PMID: 16782722)
      Teratology. 1991 Jan;43(1):41-51. (PMID: 2006471)
      Diabetologia. 1992 Jan;35(1):45-55. (PMID: 1541381)
      Rev Endocr Metab Disord. 2003 Mar;4(1):79-93. (PMID: 12618562)
      Neonatology. 2011;100(2):147-54. (PMID: 21430391)
      Diabetes Care. 2010 Mar;33(3):676-82. (PMID: 20190296)
      Environ Health Prev Med. 2018 Sep 15;23(1):45. (PMID: 30219031)
      Reprod Toxicol. 2011 Sep;32(2):205-12. (PMID: 21620955)
      Acta Obstet Gynecol Scand. 2010 Nov;89(11):1403-11. (PMID: 20929418)
      BMJ. 1990 Aug 4;301(6746):259-62. (PMID: 2390618)
      Diabetes Res Clin Pract. 2003 Apr;60(1):63-7. (PMID: 12639767)
      Ann Nutr Metab. 2017;70(1):16-25. (PMID: 28110332)
      BMC Public Health. 2014 Jan 10;14:25. (PMID: 24410977)
      Diabetologia. 1967 Jun;3(3):299-304. (PMID: 5621372)
      Gynecol Endocrinol. 2006 Sep;22(9):526-35. (PMID: 17071539)
      J Matern Fetal Neonatal Med. 2003 Oct;14(4):256-60. (PMID: 14738172)
      Diabetologia. 2006 Jan;49(1):123-31. (PMID: 16344925)
      J Pediatr. 1967 Aug;71(2):216-9. (PMID: 6029469)
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20220606 Date Completed: 20220608 Latest Revision: 20220716
    • Publication Date:
      20221213
    • Accession Number:
      PMC9170270
    • Accession Number:
      10.1371/journal.pone.0269610
    • Accession Number:
      35666987