Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science, c2005-
    • Subject Terms:
      Nuclear Proteins*/genetics ; Nuclear Proteins*/metabolism ; Synaptonemal Complex*/genetics ; Synaptonemal Complex*/metabolism; Ubiquitin-Protein Ligases/*metabolism; Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Male ; Meiosis/genetics ; Mice ; Mice, Knockout ; Spermatocytes/metabolism ; Ubiquitin-Protein Ligases/genetics
    • Abstract:
      Meiosis is a hallmark event in germ cell development that accompanies sequential events executed by numerous molecules. Therefore, characterization of these factors is one of the best strategies to clarify the mechanism of meiosis. Here, we report tripartite motif-containing 41 (TRIM41), a ubiquitin ligase E3, as an essential factor for proper meiotic progression and fertility in male mice. Trim41 knockout (KO) spermatocytes exhibited synaptonemal complex protein 3 (SYCP3) overloading, especially on the X chromosome. Furthermore, mutant mice lacking the RING domain of TRIM41, required for the ubiquitin ligase E3 activity, phenocopied Trim41 KO mice. We then examined the behavior of mutant TRIM41 (ΔRING-TRIM41) and found that ΔRING-TRIM41 accumulated on the chromosome axes with overloaded SYCP3. This result suggested that TRIM41 exerts its function on the chromosome axes. Our study revealed that Trim41 is essential for preventing SYCP3 overloading, suggesting a TRIM41-mediated mechanism for regulating chromosome axis protein dynamics during male meiotic progression.
      Competing Interests: The authors declare that they have no conflict of interest.
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    • Accession Number:
      0 (Cell Cycle Proteins)
      0 (Nuclear Proteins)
      EC 2.3.2.27 (Trim41 protein, mouse)
      EC 2.3.2.27 (Ubiquitin-Protein Ligases)
    • Publication Date:
      Date Created: 20220601 Date Completed: 20220615 Latest Revision: 20241207
    • Publication Date:
      20241209
    • Accession Number:
      PMC9191731
    • Accession Number:
      10.1371/journal.pgen.1010241
    • Accession Number:
      35648791