Increased Intra-Subject Variability of Neural Activity During Speech Production in People with Autism Spectrum Disorder.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101300021 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1750-9467 (Print) NLM ISO Abbreviation: Res Autism Spectr Disord Subsets: PubMed not MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier
    • Abstract:
      Background: Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task.
      Methods: Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm.
      Results: There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech.
      Conclusions: These findings highlight the importance of understanding intra-subject neural variability in participants with ASD.
      Competing Interests: Conflict of Interest The authors have no real or potential conflicts of interest to declare that are relevant to the content of this article.
    • References:
      Clin Psychol Rev. 2014 Feb;34(1):73-86. (PMID: 24424351)
      J Autism Dev Disord. 2011 Apr;41(4):405-26. (PMID: 20972615)
      Neuron. 2002 Jan 31;33(3):341-55. (PMID: 11832223)
      Autism Res. 2018 Feb;11(2):296-304. (PMID: 29052364)
      Autism. 2019 Nov;23(8):2131-2144. (PMID: 31067982)
      Autism Res. 2020 Oct;13(10):1718-1729. (PMID: 32881387)
      Front Psychol. 2019 May 28;10:1211. (PMID: 31191403)
      Lang Cogn Process. 2001 Apr 1;16(2-3):287-308. (PMID: 16703115)
      J Commun Disord. 2014 Jan-Feb;47:17-33. (PMID: 24491630)
      J Autism Dev Disord. 1994 Jun;24(3):247-57. (PMID: 8050980)
      Autism Res. 2020 Feb;13(2):221-229. (PMID: 31566907)
      Trends Cogn Sci. 2015 Jun;19(6):322-8. (PMID: 25979849)
      Autism. 2009 Jul;13(4):411-33. (PMID: 19535469)
      Brain Lang. 2018 Dec;187:1-8. (PMID: 30312833)
      J Autism Dev Disord. 2015 May;45(5):1176-90. (PMID: 25326820)
      J Child Lang. 2003 Feb;30(1):213-36. (PMID: 12718299)
      J Int Neuropsychol Soc. 2008 Nov;14(6):967-79. (PMID: 18954477)
      Autism Res. 2019 Apr;12(4):600-613. (PMID: 30758144)
      Brain. 2001 Oct;124(Pt 10):2059-73. (PMID: 11571222)
      Neuropsychologia. 2014 Oct;63:10-8. (PMID: 25107679)
      Autism Res. 2020 Nov;13(11):1828-1842. (PMID: 32827357)
      Mol Autism. 2013 May 15;4(1):12. (PMID: 23675638)
      Hum Brain Mapp. 1999;8(4):272-84. (PMID: 10619420)
      Autism Res. 2019 Aug;12(8):1225-1235. (PMID: 31136103)
      Autism Res. 2016 Feb;9(2):249-61. (PMID: 26363154)
      Autism Dev Lang Impair. 2019 Jan-Dec;4:. (PMID: 35155816)
      J Speech Lang Hear Res. 2007 Feb;50(1):149-60. (PMID: 17344556)
      Front Integr Neurosci. 2013 Jul 01;7:47. (PMID: 23847480)
      J Autism Dev Disord. 1999 Feb;29(1):19-31. (PMID: 10097992)
      Res Autism Spectr Disord. 2019 Jul;63:52-62. (PMID: 32565886)
      Biol Psychiatry. 2011 Aug 1;70(3):263-9. (PMID: 21392733)
      Neuroimage Clin. 2020;27:102260. (PMID: 32388347)
      Gait Posture. 2010 May;32(1):6-9. (PMID: 20400311)
      PLoS One. 2016 Aug 25;11(8):e0161637. (PMID: 27560378)
      Transl Psychiatry. 2019 Dec 18;9(1):341. (PMID: 31852886)
      Int J Lang Commun Disord. 2010 Nov-Dec;45(6):681-90. (PMID: 20102259)
      Neuron. 2010 May 13;66(3):461-9. (PMID: 20471358)
      Philos Trans R Soc Lond B Biol Sci. 2003 Feb 28;358(1430):303-14. (PMID: 12639328)
      Mol Autism. 2019 Aug 15;10:34. (PMID: 31428297)
      Neuroimage. 2001 May;13(5):903-19. (PMID: 11304086)
      Brain Res. 2008 Jul 24;1221:115-25. (PMID: 18555209)
      Am J Speech Lang Pathol. 2021 Jun 18;30(3S):1542-1557. (PMID: 33852328)
      Neurosci Lett. 1998 Mar 27;245(1):1-4. (PMID: 9596341)
      Eur J Neurosci. 2018 Mar;47(6):602-609. (PMID: 28474794)
      Neuroimage. 2006 Dec;33(4):1093-103. (PMID: 17011792)
      IEEE Trans Med Imaging. 1999 Jan;18(1):32-42. (PMID: 10193695)
      Clin Neurophysiol. 2018 Jul;129(7):1374-1382. (PMID: 29729592)
      Brain Connect. 2012;2(3):125-41. (PMID: 22642651)
      Neuroimage. 1999 Oct;10(4):417-29. (PMID: 10493900)
      J Child Psychol Psychiatry. 2006 Jun;47(6):629-38. (PMID: 16712640)
      Brain Lang. 2006 Mar;96(3):280-301. (PMID: 16040108)
      Vision Res. 2009 Nov;49(22):2705-39. (PMID: 19682485)
      J Neurophysiol. 2019 Oct 1;122(4):1330-1341. (PMID: 31314644)
      J Autism Dev Disord. 2009 May;39(5):693-705. (PMID: 19082876)
      Biol Psychiatry. 2010 Aug 15;68(4):345-51. (PMID: 20303070)
      Schizophr Res. 2016 Aug;175(1-3):12-19. (PMID: 27083780)
      Brain Cogn. 2013 Nov;83(2):218-26. (PMID: 24056237)
      J Intellect Disabil Res. 2016 May;60(5):478-90. (PMID: 27120990)
      Neuropsychol Rev. 2011 Sep;21(3):252-70. (PMID: 21842186)
      Am J Psychiatry. 2003 Oct;160(10):1847-62. (PMID: 14514501)
      Neuron. 2012 Sep 20;75(6):981-91. (PMID: 22998867)
      PLoS One. 2012;7(5):e37527. (PMID: 22662166)
      Am J Speech Lang Pathol. 2021 Jun 18;30(3S):1525-1541. (PMID: 33684309)
      J Dev Behav Pediatr. 2015 Oct;36(8):569-74. (PMID: 26114615)
      Front Psychol. 2011 Mar 30;2:51. (PMID: 21716921)
      Autism Res. 2016 Oct;9(10):1046-1057. (PMID: 26751141)
      Autism. 2020 Jul;24(5):1217-1231. (PMID: 31958998)
      Neuroimage Clin. 2014 Feb 25;4:444-53. (PMID: 25101235)
      Neurosci Biobehav Rev. 2016 Dec;71:590-600. (PMID: 27746319)
      Lang Cogn Process. 2011 Jan 1;26(7):952-981. (PMID: 23667281)
      J Autism Dev Disord. 1996 Apr;26(2):173-8. (PMID: 8744480)
      PLoS One. 2012;7(6):e38355. (PMID: 22701630)
      J Cogn Neurosci. 2008 Mar;20(3):541-52. (PMID: 18004944)
      Autism Res. 2017 Aug;10(8):1384-1391. (PMID: 28419785)
      J Autism Dev Disord. 2021 Feb;51(2):644-665. (PMID: 32588273)
      Autism. 2017 Oct;21(7):852-861. (PMID: 27354431)
      Front Psychol. 2019 Jun 04;10:1177. (PMID: 31214068)
      J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S69-78. (PMID: 16685188)
      J Autism Dev Disord. 2018 Oct;48(10):3417-3431. (PMID: 29767824)
    • Grant Information:
      P50 DC013027 United States DC NIDCD NIH HHS; R01 DC002852 United States DC NIDCD NIH HHS; R01 DC007683 United States DC NIDCD NIH HHS; T32 DC013017 United States DC NIDCD NIH HHS
    • Contributed Indexing:
      Keywords: communication; functional magnetic resonance imaging; speech; variability
    • Publication Date:
      Date Created: 20220523 Latest Revision: 20230602
    • Publication Date:
      20231215
    • Accession Number:
      PMC9119427
    • Accession Number:
      10.1016/j.rasd.2022.101955
    • Accession Number:
      35601992