Choriocapillaris flow deficit and the risk of referable diabetic retinopathy: a longitudinal SS-OCTA study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE
    • Publication Information:
      Publication: Jan. 1992- : London : BMJ Pub. Group
      Original Publication: 1917-Dec. 1991: London : British Medical Association
    • Subject Terms:
      Diabetic Retinopathy*/diagnosis ; Diabetes Mellitus, Type 2*/complications; Humans ; Middle Aged ; Aged ; Fluorescein Angiography/methods ; Prospective Studies ; Choroid ; Tomography, Optical Coherence/methods
    • Abstract:
      Aims: To investigate the association between the choriocapillaris flow deficit percentage (CC FD%) and the 1-year incidence of referable diabetic retinopathy (RDR) in participants with type 2 diabetes mellitus (DM).
      Methods: This prospective cohort study included participants with type 2 DM. The DR status was graded based on the ETDRS-7 photography. The CC FD% in the central 1 mm area, inner circle (1.5 mm to 2.5 mm), outer circle (2.5 mm to 5.0 mm) and the entire area in the macular region were measured using swept-source optical coherence tomography angiography (SS-OCTA). Logistic regression analysis was used to examine the association between baseline CC FD% and 1-year incident RDR.
      Results: A total of 1222 patients (1222 eyes, mean age: 65.1±7.4 years) with complete baseline and 1-year follow-up data were included. Each 1% increase in baseline CC FD% was significantly associated with a 1.69 times (relative risk 2.69; 95% CI 1.53 to 4.71; p=0.001) higher odds for development of RDR after 1-year follow-up, after adjusting for other confounding factors.
      Conclusions: A greater baseline CC FD% detected by SS-OCTA reliably predicted higher risks of RDR in participants with type 2 DM. Thus, CC FD% may act as a novel biomarker for predicting the onset and progression of DR.
      Competing Interests: Competing interests: None declared.
      (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
    • Contributed Indexing:
      Keywords: Anatomy; Choroid; Diagnostic tests/Investigation; Epidemiology; Imaging
    • Publication Date:
      Date Created: 20220516 Date Completed: 20230823 Latest Revision: 20230823
    • Publication Date:
      20231215
    • Accession Number:
      10.1136/bjophthalmol-2021-320704
    • Accession Number:
      35577546