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Metabolomics on vascular events and death after acute ischemic stroke: A prospective matched nested case-control study.
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- Author(s): Ke C;Ke C; Shi M; Shi M; Guo D; Guo D; Zhu Z; Zhu Z; Zhong C; Zhong C; Xu T; Xu T; Lu Y; Lu Y; Ding Y; Ding Y; Zhang Y; Zhang Y
- Source:
Atherosclerosis [Atherosclerosis] 2022 Jun; Vol. 351, pp. 1-8. Date of Electronic Publication: 2022 May 07.- Publication Type:
Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
- Publication Information: Publication: Limerick : Elsevier
Original Publication: Amsterdam, Elsevier. - Subject Terms:
- Abstract: Background and Aims: Ischemic stroke is a major contributor to global mortality and disability. Metabolomics represents a powerful tool for discovering biomarkers of ischemic stroke due to its ability to detect metabolites small enough to cross the blood-brain barrier. The aim of this study is to identify potential metabolic biomarkers for predicting 1-year vascular events and death after acute ischemic stroke (AIS).
Methods: We adopted a nested case-control design from a multicenter prospective cohort study. A total of 143 AIS patients with 1-year vascular events/death and 143 sex-, age- and center-matched patients without 1-year vascular events/death were selected, and further divided into the discovery set (n = 140) and validation set (n = 146). We then performed untargeted metabolomics analysis by liquid chromatography coupled to mass spectrometry.
Results: Metabolomics analyses could predict 1-year vascular events and death after AIS using pattern recognition methods. Eight metabolites (e.g., LysoPC(18:1)) were identified as potential biomarkers of AIS prognosis. Four of them (e.g., PS(O-18:0/0:0)) were found to be significantly decreased in patients with early vascular events/death. Adding these metabolic biomarkers to traditional factors resulted in a great improvement of the predictive utility for 1-year vascular events/death, with net reclassification index and integrated discrimination improvement being 0.9143 (p < 0.0001) and 0.1906 (p < 0.0001) in the discovery cohort, and 0.9041 (p < 0.0001) and 0.1896 (p < 0.0001) in the validation cohort.
Conclusions: This study found several metabolic biomarkers for 1-year vascular events and death after AIS, providing opportunities for the construction of prognostic models and the discovery of novel therapeutic targets.
(Copyright © 2022 Elsevier B.V. All rights reserved.) - Contributed Indexing: Keywords: Biomarker; Death; Ischemic stroke; Metabolomics; Vascular events
- Accession Number: 0 (Biomarkers)
- Publication Date: Date Created: 20220516 Date Completed: 20220608 Latest Revision: 20220627
- Publication Date: 20240829
- Accession Number: 10.1016/j.atherosclerosis.2022.05.001
- Accession Number: 35576815
- Source:
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