Metabolomics on vascular events and death after acute ischemic stroke: A prospective matched nested case-control study.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Ireland NLM ID: 0242543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1484 (Electronic) Linking ISSN: 00219150 NLM ISO Abbreviation: Atherosclerosis Subsets: MEDLINE
    • Publication Information:
      Publication: Limerick : Elsevier
      Original Publication: Amsterdam, Elsevier.
    • Subject Terms:
      Brain Ischemia*/diagnosis ; Ischemic Stroke* ; Stroke*; Biomarkers/metabolism ; Case-Control Studies ; Humans ; Metabolomics/methods ; Prognosis ; Prospective Studies
    • Abstract:
      Background and Aims: Ischemic stroke is a major contributor to global mortality and disability. Metabolomics represents a powerful tool for discovering biomarkers of ischemic stroke due to its ability to detect metabolites small enough to cross the blood-brain barrier. The aim of this study is to identify potential metabolic biomarkers for predicting 1-year vascular events and death after acute ischemic stroke (AIS).
      Methods: We adopted a nested case-control design from a multicenter prospective cohort study. A total of 143 AIS patients with 1-year vascular events/death and 143 sex-, age- and center-matched patients without 1-year vascular events/death were selected, and further divided into the discovery set (n = 140) and validation set (n = 146). We then performed untargeted metabolomics analysis by liquid chromatography coupled to mass spectrometry.
      Results: Metabolomics analyses could predict 1-year vascular events and death after AIS using pattern recognition methods. Eight metabolites (e.g., LysoPC(18:1)) were identified as potential biomarkers of AIS prognosis. Four of them (e.g., PS(O-18:0/0:0)) were found to be significantly decreased in patients with early vascular events/death. Adding these metabolic biomarkers to traditional factors resulted in a great improvement of the predictive utility for 1-year vascular events/death, with net reclassification index and integrated discrimination improvement being 0.9143 (p < 0.0001) and 0.1906 (p < 0.0001) in the discovery cohort, and 0.9041 (p < 0.0001) and 0.1896 (p < 0.0001) in the validation cohort.
      Conclusions: This study found several metabolic biomarkers for 1-year vascular events and death after AIS, providing opportunities for the construction of prognostic models and the discovery of novel therapeutic targets.
      (Copyright © 2022 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Biomarker; Death; Ischemic stroke; Metabolomics; Vascular events
    • Accession Number:
      0 (Biomarkers)
    • Publication Date:
      Date Created: 20220516 Date Completed: 20220608 Latest Revision: 20220627
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.atherosclerosis.2022.05.001
    • Accession Number:
      35576815