Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0370506 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-2990 (Electronic) Linking ISSN: 00029629 NLM ISO Abbreviation: Am J Med Sci Subsets: MEDLINE
    • Publication Information:
      Publication: 2016- : New York : Elsevier
      Original Publication: Philadelphia : J. B. Lippincott
    • Subject Terms:
      Scleroderma, Systemic*/complications ; Acute Kidney Injury*/etiology ; Scleroderma, Localized* ; Vascular Diseases*/etiology ; Ureteral Diseases*; Humans ; Peroxidase ; Antibodies, Antineutrophil Cytoplasmic ; Kidney ; Penicillamine
    • Abstract:
      The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma. Scleroderma renal crisis, myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis, penicillamine-associated renal disease, abnormal urinalysis, alteration of vascular endothelial markers, scleroderma associated-vasculopathy with abnormal renal resistance indices and cardiorenal syndromes type 5 were also reported in SSc patients. A frequent form of renal involvement in SSc patients is a subclinical renal vasculopathy, characterized by vascular damage and normal renal function. Indeed, asymptomatic renal changes, expressed by increase of intrarenal stiffness, are often non-progressive in SSc patients but can lead to a reduction in renal functional reserve. The purpose of this review is to provide an assessment of kidney involvement in SSc, from SRC to subclinical renal vasculopathy.
      Competing Interests: Declaration of Competing Interest The author has no financial or other conflicts of interest to disclose.
      (Copyright © 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Chronic kidney disease; Renal Doppler ultrasonography; Renal vasculopathy; Systemic sclerosis
    • Accession Number:
      EC 1.11.1.7 (Peroxidase)
      0 (Antibodies, Antineutrophil Cytoplasmic)
      GNN1DV99GX (Penicillamine)
    • Publication Date:
      Date Created: 20220510 Date Completed: 20221024 Latest Revision: 20230124
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/j.amjms.2022.02.014
    • Accession Number:
      35537505