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Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes: Results from DAPASALT and DIAMOND.
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- Author(s): Sen T;Sen T; Scholtes R; Scholtes R; Greasley PJ; Greasley PJ; Cherney DZI; Cherney DZI; Dekkers CCJ; Dekkers CCJ; Vervloet M; Vervloet M; Danser AHJ; Danser AHJ; Barbour SJ; Barbour SJ; Karlsson C; Karlsson C; Hammarstedt A; Hammarstedt A; Li Q; Li Q; Laverman GD; Laverman GD; Bjornstad P; Bjornstad P; Bjornstad P; van Raalte DH; van Raalte DH; Heerspink HJL; Heerspink HJL; Heerspink HJL
- Source:
Diabetes, obesity & metabolism [Diabetes Obes Metab] 2022 Aug; Vol. 24 (8), pp. 1578-1587. Date of Electronic Publication: 2022 Jun 01.- Publication Type:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural- Language:
English - Source:
- Additional Information
- Source: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
- Publication Information: Original Publication: Oxford : Wiley-Blackwell, c1999-
- Subject Terms: Diabetes Mellitus, Type 2*/drug therapy ; Renal Insufficiency, Chronic*/complications ; Renal Insufficiency, Chronic*/drug therapy ; Sodium-Glucose Transporter 2 Inhibitors*/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use; Aged ; Aldosterone ; Benzhydryl Compounds/pharmacology ; Benzhydryl Compounds/therapeutic use ; Biomarkers ; Blood Pressure ; Glomerular Filtration Rate ; Glucose/pharmacology ; Glucosides ; Humans ; Middle Aged ; Renin ; Sodium
- Abstract: Aims: To assess the effect of sodium-glucose cotransporter-2 inhibitor dapagliflozin on natriuresis, blood pressure (BP) and volume status in patients with chronic kidney disease (CKD) without diabetes.
Materials and Methods: We performed a mechanistic open-label study (DAPASALT) to evaluate the effects of dapagliflozin on 24-hour sodium excretion, 24-hour BP, extracellular volume, and markers of volume status during a standardized sodium diet (150 mmol/d) in six patients with CKD. In parallel, in a placebo-controlled double-blind crossover trial (DIAMOND), we determined the effects of 6 weeks of dapagliflozin on markers of volume status in 53 patients with CKD.
Results: In DAPASALT (mean age 65 years, mean estimated glomerular filtration rate [eGFR] 39.4 mL/min/1.73 m 2 , median urine albumin:creatinine ratio [UACR] 111 mg/g), dapagliflozin did not change 24-hour sodium and volume excretion during 2 weeks of treatment. Dapagliflozin was associated with a modest increase in 24-hour glucose excretion on Day 4, which persisted at Day 14 and reversed to baseline after discontinuation. Mean 24-hour systolic BP decreased by -9.3 (95% confidence interval [CI] -19.1, 0.4) mmHg after 4 days and was sustained at Day 14 and at wash-out. Renin, angiotensin II, urinary aldosterone and copeptin levels increased from baseline. In DIAMOND (mean age 51 years, mean eGFR 59.0 mL/min/1.73 m 2 , median UACR 608 mg/g), compared to placebo, dapagliflozin increased plasma renin (38.5 [95% CI 7.4, 78.8]%), aldosterone (19.1 [95% CI -5.9, 50.8]%), and copeptin levels (7.3 [95% CI 0.1, 14.5] pmol/L).
Conclusions: During a standardized sodium diet, dapagliflozin decreased BP but did not increase 24-hour sodium and volume excretion. The lack of increased natriuresis and diuresis may be attributed to activation of intra-renal compensatory mechanisms to prevent excessive water loss.
(© 2022 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.) - References: Am Heart J. 1983 Jul;106(1 Pt 2):185-7. (PMID: 6869200)
N Engl J Med. 2020 Oct 8;383(15):1436-1446. (PMID: 32970396)
Adv Ther. 2017 Feb;34(2):436-451. (PMID: 27981497)
Diabetes Care. 2021 Aug;44(8):1894-1897. (PMID: 34183431)
JCI Insight. 2018 Apr 19;3(8):. (PMID: 29669938)
Lancet Diabetes Endocrinol. 2020 Jul;8(7):582-593. (PMID: 32559474)
Diabetes Care. 2017 Jun;40(6):771-776. (PMID: 28325783)
Circulation. 2016 Sep 6;134(10):752-72. (PMID: 27470878)
Diabetes Care. 2021 Feb;44(2):440-447. (PMID: 33318125)
J Am Heart Assoc. 2020 May 5;9(9):e015716. (PMID: 32326806)
Adv Ther. 2015 Aug;32(8):768-82. (PMID: 26280756)
Cardiovasc Diabetol. 2014 Jan 29;13:28. (PMID: 24475922)
Diabetes Obes Metab. 2013 Sep;15(9):853-62. (PMID: 23668478)
Cardiovasc Diabetol. 2017 Oct 23;16(1):138. (PMID: 29061124)
J Pharmacol Exp Ther. 2020 Oct;375(1):76-91. (PMID: 32764153)
Diabetes Obes Metab. 2015 Dec;17(12):1180-93. (PMID: 26343814)
Mol Cell Biochem. 2019 Sep;459(1-2):121-130. (PMID: 31127491)
Cardiovasc Diabetol. 2018 Jul 30;17(1):108. (PMID: 30060748)
J Am Heart Assoc. 2018 Feb 10;7(4):. (PMID: 29440005)
Diabetes Obes Metab. 2014 Nov;16(11):1087-95. (PMID: 24939043)
N Engl J Med. 2019 Jun 13;380(24):2295-2306. (PMID: 30990260)
Cardiovasc Diabetol. 2019 Mar 29;18(1):44. (PMID: 30922297)
Diabetes Obes Metab. 2022 Aug;24(8):1578-1587. (PMID: 35478433)
N Engl J Med. 2019 Nov 21;381(21):1995-2008. (PMID: 31535829)
Diabetes Obes Metab. 2021 Jul;23(7):1614-1623. (PMID: 33729664)
Diab Vasc Dis Res. 2021 Jan-Feb;18(1):1479164121995928. (PMID: 33611925)
Clin Pharmacol Ther. 2009 May;85(5):513-9. (PMID: 19129749)
Circulation. 2020 Nov 3;142(18):1713-1724. (PMID: 32865004)
Lancet Diabetes Endocrinol. 2021 Jan;9(1):22-31. (PMID: 33338413)
Front Physiol. 2012 Jun 26;3:217. (PMID: 22745630)
Circulation. 2017 Sep 19;136(12):1167-1169. (PMID: 28923906) - Grant Information: P30 DK048520 United States DK NIDDK NIH HHS; P30 DK116073 United States DK NIDDK NIH HHS; R21 DK129720 United States DK NIDDK NIH HHS; K23 DK116720 United States DK NIDDK NIH HHS; R01 DK129211 United States DK NIDDK NIH HHS
- Contributed Indexing: Keywords: SGLT2 inhibitor; adaptive response; dapagliflozin; kidney
- Accession Number: 0 (Benzhydryl Compounds)
0 (Biomarkers)
0 (Glucosides)
0 (Sodium-Glucose Transporter 2 Inhibitors)
1ULL0QJ8UC (dapagliflozin)
4964P6T9RB (Aldosterone)
9NEZ333N27 (Sodium)
EC 3.4.23.15 (Renin)
IY9XDZ35W2 (Glucose) - Publication Date: Date Created: 20220428 Date Completed: 20220708 Latest Revision: 20230608
- Publication Date: 20240628
- Accession Number: PMC9262818
- Accession Number: 10.1111/dom.14729
- Accession Number: 35478433
- Source:
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