Strengths and Challenges of Closed-Loop Insulin Delivery During Exercise in People With Type 1 Diabetes: Potential Future Directions.

Publisher: Sage Country of Publication: United States NLM ID: 101306166 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-2968 (Electronic) Linking ISSN: 19322968 NLM ISO Abbreviation: J Diabetes Sci Technol Subsets: MEDLINE

Publication: 2014- : Thousand Oaks, CA : Sage
Original Publication: Foster City, CA : Diabetes Technology Society

Diabetes Mellitus, Type 1*/drug therapy ; Hypoglycemia*/chemically induced ; Hypoglycemia*/prevention & control ; Pancreas, Artificial*; Humans ; Insulin/therapeutic use ; Blood Glucose ; Insulin Infusion Systems ; Insulin, Regular, Human/therapeutic use

Exercise has many physical and psychological benefits and is recommended for people with type 1 diabetes; however, there are many barriers to exercise, including glycemic instability and fear of hypoglycemia. Closed-loop (CL) systems have shown benefit in the overall glycemic management of type 1 diabetes, including improving HbA1c levels and reducing the incidence of nocturnal hypoglycemia; however, these systems are challenged by the rapidly changing insulin needs with exercise. This commentary focuses on the principles, strengths, and challenges of CL in the management of exercise, and discusses potential approaches, including the use of additional physiological signals, to address their shortcomings in the pursuit of fully automated CL systems.

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Keywords: artificial pancreas; closed loop; exercise; type 1 diabetes

0 (Insulin)
0 (Blood Glucose)
0 (Insulin, Regular, Human)

Date Created: 20220425 Date Completed: 20230703 Latest Revision: 20230717

20230717

PMC10347984

10.1177/19322968221088327

35466723