[Effect of mutation in phoB and phoM genes for the positive control of alkaline phosphatase biosynthesis on Escherichia coli envelope proteins].

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  • Author(s): Tsfasman IM; Nesmeianova MA; Kulaev IS
  • Source:
    Molekuliarnaia biologiia [Mol Biol (Mosk)] 1986 Sep-Oct; Vol. 20 (5), pp. 1290-8.
  • Publication Type:
    Journal Article
  • Language:
    Russian
  • Additional Information
    • Transliterated Title:
      Vliianie mutatsiĭ v genakh phoB i phoM polozhitel'bogo kontrolia biosinteza shchelochnoĭ fosfatazy na belki obolochki Escherichia coli.
    • Source:
      Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Moskva : Izdatelstvo Nauka
    • Subject Terms:
      Genes, Bacterial* ; Genes, Regulator*; Alkaline Phosphatase/*biosynthesis ; Bacterial Proteins/*genetics ; Escherichia coli/*genetics; Alkaline Phosphatase/genetics ; Bacterial Outer Membrane Proteins/genetics ; Escherichia coli/enzymology ; Mutation
    • Abstract:
      The suppression of some envelope proteins, localized in both the periplasm and the outer and inner membranes was shown in phoB and phoM phoR mutants of E. coli. Among these proteins are the proteins of the phosphate regulon and also those not pertaining them. As a result of phoB and phoM phoR mutations, the cytoplasmic membrane was found to be lacking in minor protein of 28,000 Mr, which belongs to the phosphate regulon. Besides, the phoM phoR mutation leads to the loss of protein of 55,000 Mr of the outer membranes, whereas phoB mutation causes loss of protein 37 000 Mr, identified as outer membrane protein OmpT. A damage in the phoB mutant of the protein proteolytic modification, probably determining the suppression of the biosynthesis of E. coli envelope secreted proteins is suggested.
    • Accession Number:
      0 (Bacterial Outer Membrane Proteins)
      0 (Bacterial Proteins)
      EC 3.1.3.1 (Alkaline Phosphatase)
    • Publication Date:
      Date Created: 19860901 Date Completed: 19861216 Latest Revision: 20201209
    • Publication Date:
      20221208
    • Accession Number:
      3534547