Recurrent cerebellar liponeurocytoma with anaplastic features at initial presentation: A case report.

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  • Author(s): Maharaj M; Tawfik S; Ziad F; Muthu T
  • Source:
    Clinical neuropathology [Clin Neuropathol] 2022 Jul-Aug; Vol. 41 (4), pp. 168-173.
  • Publication Type:
    Case Reports; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Dustri-Verlag Country of Publication: Germany NLM ID: 8214420 Publication Model: Print Cited Medium: Internet ISSN: 0722-5091 (Print) Linking ISSN: 07225091 NLM ISO Abbreviation: Clin Neuropathol Subsets: MEDLINE
    • Publication Information:
      Publication: Munich : Dustri-Verlag
      Original Publication: München-Deisenhofen : Dustri-Verlag, [c1982-
    • Subject Terms:
    • Abstract:
      Background: Cerebellar liponeurocytoma is a rare entity with fewer than 100 reported cases and series in the available literature to date. Although the cerebellum remains the typical primary site, the entity has been shown to demonstrate increased aggressiveness and malignant progression with multiple recurrences.
      Case Description: We present a unique case in a 64-year-old gentleman of a cerebellar liponeurocytoma with multiple recurrences and progressive anaplasia. The tumor showed anaplastic features at first presentation and recurred in a more aggressive fashion in a short 2-year period despite surgical debulking and post-operative radiotherapy. It re-recurred within 6 months with subsequent re-debulking without further radiotherapy. At latest follow-up almost 3 years since surgical management of the patient's second recurrence, the patient remains well with minimal neurological impairment and no radiological signs of recurrence.
      Conclusion: Cerebellar liponeurocytoma may present with increasingly atypical histological features that may warrant more aggressive post-operative treatment to prevent disease recurrence and clinical deterioration. This may include a more aggressive surgical resection margin and consideration of adjuvant radiotherapy in all cases.
    • Publication Date:
      Date Created: 20220328 Date Completed: 20220629 Latest Revision: 20220629
    • Publication Date:
      20231215
    • Accession Number:
      10.5414/NP301403
    • Accession Number:
      35343427