Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signalling.

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  • Additional Information
    • Source:
      Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9616368 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1440-1843 (Electronic) Linking ISSN: 13237799 NLM ISO Abbreviation: Respirology Subsets: MEDLINE
    • Publication Information:
      Original Publication: Carlton, Vic. : Blackwell Science, c1996-
    • Subject Terms:
      Cell Adhesion Molecules*/genetics ; Fibroblast Growth Factor 2*/metabolism ; Hypertension, Pulmonary* ; Macrophages*/metabolism; Animals ; Disease Models, Animal ; Endothelial Cells/metabolism ; Humans ; Mice ; Mice, Knockout ; Pulmonary Artery/pathology ; Vascular Endothelial Growth Factor A/metabolism
    • Abstract:
      Background and Objective: Remodelling of pulmonary arteries (PA) contributes to the progression of pulmonary hypertension (PH). Periostin, a matricellular protein, has been reported to be involved in the development of PH. We examined the role of periostin in the pathogenesis of PH using different types of experimental PH.
      Methods: PH was induced by vascular endothelial growth factor receptor antagonist (Sugen5416) plus hypoxic exposure (SuHx) and venous injection of monocrotaline-pyrrole (MCT-P) in wild-type (WT) and periostin -/- mice. Pulmonary haemodynamics, PA remodelling, expression of chemokines and fibroblast growth factor (FGF)-2, accumulation of macrophages to small PA and the right ventricle (RV) were examined in PH-induced WT and periostin -/- mice. Additionally, the role of periostin in the migration of macrophages, human PA smooth muscle (HPASMCs) and endothelial cells (HPMVECs) was investigated.
      Results: In PH induced by SuHx and MCT-P, PH and accumulation of M2 macrophage to small PA were attenuated in periostin -/- mice. PA remodelling post-SuHx treatment was also mild in periostin -/- mice compared to WT mice. Expression of macrophage-associated chemokines and FGF-2 in lung tissue, and accumulation of CD68-positive cells in the RV were less in SuHx periostin -/- than in SuHx WT mice. Periostin secretion in HPASMCs and HPMVECs was enhanced by transforming growth factor-β. Periostin also augmented macrophage, HPASMCs and HPMVECs migration. Separately, serum periostin levels were significantly elevated in patients with PH compared to healthy controls.
      Conclusion: Periostin is involved in the development of different types of experimental PH, and may also contribute to the pathogenesis of human PH.
      (© 2022 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology.)
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    • Grant Information:
      R01 HL148165 United States HL NHLBI NIH HHS
    • Contributed Indexing:
      Keywords: M2 macrophage; experimental pulmonary hypertension; fibroblast growth factor; periostin; vascular remodelling
    • Accession Number:
      0 (Cell Adhesion Molecules)
      0 (Postn protein, mouse)
      0 (Vascular Endothelial Growth Factor A)
      103107-01-3 (Fibroblast Growth Factor 2)
    • Publication Date:
      Date Created: 20220323 Date Completed: 20220620 Latest Revision: 20240901
    • Publication Date:
      20240901
    • Accession Number:
      PMC9313806
    • Accession Number:
      10.1111/resp.14249
    • Accession Number:
      35318760