Regulation of gene expression by glycolytic and gluconeogenic enzymes.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Publishers Country of Publication: England NLM ID: 9200566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3088 (Electronic) Linking ISSN: 09628924 NLM ISO Abbreviation: Trends Cell Biol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Cambridge, UK : Elsevier Science Publishers, c1991-
    • Subject Terms:
      Gluconeogenesis*/genetics ; Glycolysis*/genetics; Gene Expression Regulation ; Glucose/metabolism ; Humans
    • Abstract:
      Gene transcription and cell metabolism are two fundamental biological processes that mutually regulate each other. Upregulated or altered expression of glucose metabolic genes in glycolysis and gluconeogenesis is a major driving force of enhanced aerobic glycolysis in tumor cells. Importantly, glycolytic and gluconeogenic enzymes in tumor cells acquire moonlighting functions and directly regulate gene expression by modulating chromatin or transcriptional complexes. The mutual regulation between cellular metabolism and gene expression in a feedback mechanism constitutes a unique feature of tumor cells and provides specific molecular and functional targets for cancer treatment.
      Competing Interests: Declaration of interests The authors declare no interests.
      (Copyright © 2022 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: cancer; gene expression; gluconeogenesis; glycolysis; metabolism
    • Accession Number:
      IY9XDZ35W2 (Glucose)
    • Publication Date:
      Date Created: 20220318 Date Completed: 20220816 Latest Revision: 20221013
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.tcb.2022.02.003
    • Accession Number:
      35300892