Favorable fatty acid composition in adipose tissue in healthy Iraqi- compared to Swedish-born men - a pilot study using MRI assessment.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101567863 Publication Model: Print Cited Medium: Internet ISSN: 2162-397X (Electronic) Linking ISSN: 21623945 NLM ISO Abbreviation: Adipocyte Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Philadelphia, PA : Taylor & Francis
      Original Publication: Austin, TX : Landes Bioscience
    • Subject Terms:
      Fatty Acids* ; Insulin Resistance*; Adipose Tissue ; Case-Control Studies ; Humans ; Intra-Abdominal Fat/pathology ; Iraq ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pilot Projects ; Sweden
    • Abstract:
      Middle Eastern immigrants are at high-risk for insulin resistance. Fatty acid composition (FAC) plays an important role in the development of insulin resistance but has not been investigated in people of Middle Eastern ancestry. Here, the aim was to assess the FAC in visceral and subcutaneous adipose tissue (VAT and SAT) in healthy Iraqi- and Swedish-born men using a magnetic resonance imaging (MRI) method.This case-control study included 23 Iraqi- and 15 Swedish-born middle-aged men, without cardiometabolic disease. Using multi-echo MRI of the abdomen, the fractions of saturated, monounsaturated, and polyunsaturated fatty acids (fSFA, fMUFA, and fPUFA) were estimated in VAT and SAT. SAT was further analyzed in deep and superficial compartments (dSAT and sSAT).In all depots, fPUFA was significantly higher and fSFA significantly lower in Iraqi men, independently of age and BMI. In both Iraqi- and Swedish-born men, higher fPUFA and lower fMUFA were found in sSAT vs. dSAT. Among Iraqi men only, higher fPUFA and lower fMUFA were found in SAT vs. VAT.Iraqi-born men presented a more favorable abdominal FAC compared to Swedish-born men. This MRI method also revealed different FACs in different abdominal depots. Our results may reflect a beneficial FAC in Middle Eastern immigrants.
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    • Contributed Indexing:
      Keywords: Adipose tissue composition; MRI; cardiometabolic disease; migration; water-fat imaging
    • Accession Number:
      0 (Fatty Acids)
    • Publication Date:
      Date Created: 20220316 Date Completed: 20220504 Latest Revision: 20220504
    • Publication Date:
      20240829
    • Accession Number:
      PMC8928862
    • Accession Number:
      10.1080/21623945.2022.2042963
    • Accession Number:
      35291924