Inflamatorni miofibroblastni tumor larinksa.

Inflammatory myofibroblastic tumor of the larynx.

Background/Aim. Inflammatory myofibroblastic tumor (IMT) of the larynx is a rare borderline lesion composed of myofibroblastic and inflammatory cells. Case report. We presented a case of 77-year-old male with hoarseness for about three months. Laryngoscopy showed a polypoid tumor originated from the anterior commissure with glottic projection. Grossly, the tumor was 22 x 15 mm, whitish, oval nodus with firm consistency. Histologically, the lesion was composed of spindled to stellate cells arranged in a fascicular to storiform pattern and inflammatory cells: lymphocytes, histiocytes, plasma cells and neutrophils. The stroma was fibromyxoid and collagenous. Immunohistochemically, tumor cells showed strong positivity for actin and vimentin and negativity for cytokeratin, CD34, S100 and desmin. The proliferation (Ki67) was less than 10%. Conclusion. Inflammatory myofibroblastic tumor may be mistaken as a malignancy and the differential diagnosis can be difficult without immunohistochemistry. It is critical to recognize this uncommon entity to avoid unnecessary aggressive treatment. [ABSTRACT FROM AUTHOR]

Uvod/Cilj. Inflamatorni miofibroblastni tumor (IMT) larinksa retka je iviĆna (bordeline) lezija sastavljena od miofibroblastnih i inflamatornih čelija. Prikaz bolesnika. Prikazan je bolesnik starosti 77 godina, sa promuklošču u trajanju od oko tri meseca. Laringoskopski je uoĆen polipoidni tumor koji je polazio sa prednje komisure i spuštao se u glotis. Makroskopski, tumor je bio ovalni, beliĆasti nodus, promera 22 x 15 mm, Ćvrste konzistencije. Histološki, lezija se sastojala od čelija vretenastog do zvezdastog oblika koje su bile grupisane u snopove i storiformna podruĆja i inflamatornih čelija: limfocita, histiocita, plazmocita i neutrofila. Stroma je bila fibromiksoidna i kolagena. Imunohistohemijski, tumorske čelije su pokazivale jako pozitivnu reakciju na aktin i vimentin, a negativnu na citokeratin, CD34, S100 i dezmin. Proliferacija čelija (Ki67) iznosila je manje od 10%. ZakljuĆak. Inflamatorni miofibroblastni tumor može se zameniti malignitetom, pa je diferencijalna dijagnoza teška bez imunohistohemijskih ispitivanja. Prepoznavanje ovog retkog entiteta je od presudnog znaĆaja da bi se izbeglo nepotrebno agresivno leĆenje. [ABSTRACT FROM AUTHOR]

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