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Protective effects of neuropeptide Y against elastase-induced pulmonary emphysema.
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- Author(s): Taniguchi A;Taniguchi A;Taniguchi A; Oda N; Oda N; Morichika D; Morichika D; Senoo S; Senoo S; Itano J; Itano J; Fujii U; Fujii U; Guo L; Guo L; Sunami R; Sunami R; Kiura K; Kiura K; Maeda Y; Maeda Y; Miyahara N; Miyahara N; Miyahara N
- Source:
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2022 Apr 01; Vol. 322 (4), pp. L539-L549. Date of Electronic Publication: 2022 Feb 02.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1504 (Electronic) Linking ISSN: 10400605 NLM ISO Abbreviation: Am J Physiol Lung Cell Mol Physiol Subsets: MEDLINE
- Publication Information: Original Publication: Bethesda, MD : American Physiological Society, c1989-
- Subject Terms: Emphysema* ; Pulmonary Emphysema*/chemically induced ; Pulmonary Emphysema*/drug therapy ; Pulmonary Emphysema*/prevention & control; Animals ; Bronchoalveolar Lavage Fluid ; Chemokines/metabolism ; Humans ; Immunity, Innate ; Lung/metabolism ; Lymphocytes ; Mice ; Mice, Inbred C57BL ; Neuropeptide Y/metabolism ; Neuropeptide Y/pharmacology ; Pancreatic Elastase/metabolism ; Swine
- Abstract: Neuropeptide Y (NPY) is a neuropeptide widely expressed in not only the central nervous system but also immune cells and the respiratory epithelium. Patients with chronic obstructive pulmonary disease (COPD) reportedly exhibit decreased NPY expression in the airway epithelium, but the involvement of NPY in the pathophysiology of COPD has not been defined. We investigated the role of NPY in elastase-induced emphysema. NPY-deficient (NPY -/- ) mice and wild-type (NPY +/+ ) mice received intratracheal instillation of porcine pancreas elastase (PPE). The numbers of inflammatory cells and the levels of cytokines and chemokines in the bronchoalveolar lavage (BAL) fluid and lung homogenates were determined along with quantitative morphometry of lung sections. Intratracheal instillation of PPE induced emphysematous changes and increased NPY levels in the lungs. Compared with NPY +/+ mice, NPY -/- mice had significantly enhanced PPE-induced emphysematous changes and alveolar enlargement. Neutrophilia seen in BAL fluid of NPY +/+ mice on day 4 after PPE instillation was also enhanced in NPY -/- mice, and the enhancement was associated with increased levels of neutrophil-related and macrophage-related chemokines and IL-17A as well as increased numbers of type 3 innate lymphoid cells in the airways. Treatment with NPY significantly reduced PPE-induced emphysematous changes. Conversely, treatment with a NPY receptor antagonist exacerbated PPE-induced emphysematous changes. These observations indicate that NPY has protective effects against elastase-induced emphysema and suggest that targeting NPY in emphysema has potential as a therapeutic strategy for delaying disease progression.
- Contributed Indexing: Keywords: COPD; IL-17A; ILC3; NPY; emphysema
- Molecular Sequence: figshare 10.6084/m9.figshare.19105463.v1
- Accession Number: 0 (Chemokines)
0 (Neuropeptide Y)
EC 3.4.21.36 (Pancreatic Elastase) - Publication Date: Date Created: 20220202 Date Completed: 20220502 Latest Revision: 20220502
- Publication Date: 20240829
- Accession Number: 10.1152/ajplung.00353.2020
- Accession Number: 35107033
- Source:
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