[Regional myocardial blood flow quantitatively measured using O-15 water and dynamic positron emission tomography].

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8804703 Publication Model: Print Cited Medium: Print ISSN: 0914-5087 (Print) Linking ISSN: 09145087 NLM ISO Abbreviation: J Cardiol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Tokyo : Japanese College Of Cardiology
    • Subject Terms:
      Coronary Circulation* ; Oxygen Radioisotopes* ; Tomography, Emission-Computed*; Angina Pectoris/*physiopathology ; Myocardial Infarction/*physiopathology; Adult ; Aged ; Angina Pectoris/diagnostic imaging ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnostic imaging ; Water
    • Abstract:
      This study was performed to measure regional myocardial blood flow (MBF) quantitatively using dynamic positron emission tomography (PET) and O-15 water. The subjects consisted of two normal volunteers, four patients with normal coronary angiograms (CAG), two patients with angina pectoris (3-vessel disease) and three patients with myocardial infarction. O-15 water (15-20 mCi) was injected via the cubital vein in a bolus, and dynamic PET was performed. MBF was calculated according to the method of Iida. The region of interest (ROI) was selected on the left ventricular wall (septum, anterior and lateral walls) and MBF was calculated in each ROI. In normal volunteers, MBF was 1.07 to 1.17 ml/g/min. It was 0.96 to 1.02 ml/g/min in patients with normal CAG, and 0.53 to 0.64 ml/g/min in patients with angina pectoris in the ischemic area. In patients with myocardial infarction, MBF was so diminished in the infarcted area as detected by 2-DE or ECG that the absolute value was almost 0 ml/g/min. In patients with angina pectoris, there was no definite defect on the MBF image, but we could estimate the severity of coronary stenosis by quantifying the MBF. The clinical advantages of this method include estimation of the severity of coronary arterial stenosis in the resting state.
    • Accession Number:
      0 (Oxygen Radioisotopes)
      059QF0KO0R (Water)
    • Publication Date:
      Date Created: 19871201 Date Completed: 19890329 Latest Revision: 20161123
    • Publication Date:
      20221213
    • Accession Number:
      3509832