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Intramolecular carbon isotope signals reflect metabolite allocation in plants.
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- Additional Information
- Source:
Publisher: Oxford University Press Country of Publication: England NLM ID: 9882906 Publication Model: Print Cited Medium: Internet ISSN: 1460-2431 (Electronic) Linking ISSN: 00220957 NLM ISO Abbreviation: J Exp Bot Subsets: MEDLINE
- Publication Information:
Original Publication: Oxford, UK : Oxford University Press,
- Subject Terms:
- Abstract:
Stable isotopes at natural abundance are key tools to study physiological processes occurring outside the temporal scope of manipulation and monitoring experiments. Whole-molecule carbon isotope ratios (13C/12C) enable assessments of plant carbon uptake yet conceal information about carbon allocation. Here, we identify an intramolecular 13C/12C signal at tree-ring glucose C-5 and C-6 and develop experimentally testable theories on its origin. More specifically, we assess the potential of processes within C3 metabolism for signal introduction based (inter alia) on constraints on signal propagation posed by metabolic networks. We propose that the intramolecular signal reports carbon allocation into major metabolic pathways in actively photosynthesizing leaf cells including the anaplerotic, shikimate, and non-mevalonate pathway. We support our theoretical framework by linking it to previously reported whole-molecule 13C/12C increases in cellulose of ozone-treated Betula pendula and a highly significant relationship between the intramolecular signal and tropospheric ozone concentration. Our theory postulates a pronounced preference for leaf cytosolic triose-phosphate isomerase to catalyse the forward reaction in vivo (dihydroxyacetone phosphate to glyceraldehyde 3-phosphate). In conclusion, intramolecular 13C/12C analysis resolves information about carbon uptake and allocation enabling more comprehensive assessments of carbon metabolism than whole-molecule 13C/12C analysis.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Experimental Biology.)
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- Grant Information:
2013-05219 Swedish Research Council; Knut and Alice Wallenberg Foundation; 2015.0047 'NMR for Life'; Kempe foundations; DE-FG02-91ER2002 U.S. Department of Energy; Michigan AgBioResearch
- Contributed Indexing:
Keywords: Carbon allocation; carbon stable isotopes; intramolecular isotope analysis; long time scales; ozone stress; primary carbon metabolism; triose-phosphate isomerase
- Accession Number:
0 (Carbon Isotopes)
7440-44-0 (Carbon)
IY9XDZ35W2 (Glucose)
- Publication Date:
Date Created: 20220127 Date Completed: 20220420 Latest Revision: 20220716
- Publication Date:
20240829
- Accession Number:
PMC9015809
- Accession Number:
10.1093/jxb/erac028
- Accession Number:
35084456
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