Clinical nephrotoxicity induced by cyclosporin A combined with hormone therapy for nephrotic syndrome.

Publisher: Faculty of Pharmacy, University of Karachi Country of Publication: Pakistan NLM ID: 9426356 Publication Model: Print Cited Medium: Internet ISSN: 1011-601X (Print) Linking ISSN: 1011601X NLM ISO Abbreviation: Pak J Pharm Sci Subsets: MEDLINE

Original Publication: Karachi : Faculty of Pharmacy, University of Karachi, [1988-

Cyclosporine/*adverse effects ; Glucocorticoids/*adverse effects ; Immunosuppressive Agents/*adverse effects ; Nephrotic Syndrome/*drug therapy ; Prednisone/*adverse effects ; Proteinuria/*chemically induced; Administration, Oral ; Adolescent ; Adult ; Aged ; Biomarkers/blood ; Biomarkers/urine ; Creatinine/blood ; Cyclosporine/administration & dosage ; Cyclosporine/blood ; Female ; Glucocorticoids/administration & dosage ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/blood ; Lipids/blood ; Male ; Middle Aged ; Nephrotic Syndrome/blood ; Nephrotic Syndrome/diagnosis ; Prednisone/administration & dosage ; Proteinuria/blood ; Proteinuria/diagnosis ; Proteinuria/urine ; Risk Assessment ; Risk Factors ; Tablets ; Time Factors ; Treatment Outcome ; Young Adult

This study aims to explore the nephrotoxicity due to use of combination of cyclosporine A and hormone in the treatment of nephrotic syndrome. From January 2018 to November 2019, 100 patients with primary nephrotic syndrome were divided into experimental and control groups, with 50 patients per group. The experimental group took oral cyclosporine A and prednisone tablets, while the control group received oral cyclosporine A combined with shock therapy. The contents of white blood cells, triglycerides, urine protein and cholesterol in the experimental group were lower than those in the control group, while their albumin content was significantly higher than the control values. Blood concentrations of cyclosporine A were significantly lower in non-nephrotoxic patients than in nephrotoxic patients. The high blood cyclosporine A level in patients (>200ng/mL) may be a factor for inducement of nephrotoxicity. Basal serum creatinine levels in nephrotoxic patients were significantly higher than those in non-nephrotoxic patients. Therefore, high basal creatinine level may be a contributing factor to nephrotoxicity. The combination of cyclosporine A and hormone is effective in the treatment of nephrotic syndrome. Blood cyclosporine A levels greater than 200ng/ml or elevated basal serum creatinine may be the cause of nephrotoxicity.

0 (Biomarkers)
0 (Glucocorticoids)
0 (Immunosuppressive Agents)
0 (Lipids)
0 (Tablets)
83HN0GTJ6D (Cyclosporine)
AYI8EX34EU (Creatinine)
VB0R961HZT (Prednisone)

Date Created: 20220118 Date Completed: 20220315 Latest Revision: 20220315

20231215

35039257