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Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort study.
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- Author(s): Esperatti M;Esperatti M;Esperatti M; Busico M; Busico M; Busico M; Fuentes NA; Fuentes NA; Fuentes NA; Gallardo A; Gallardo A; Gallardo A; Osatnik J; Osatnik J; Osatnik J; Vitali A; Vitali A; Wasinger EG; Wasinger EG; Wasinger EG; Olmos M; Olmos M; Quintana J; Quintana J; Saavedra SN; Saavedra SN; Lagazio AI; Lagazio AI; Andrada FJ; Andrada FJ; Andrada FJ; Kakisu H; Kakisu H; Romano NE; Romano NE; Matarrese A; Matarrese A; Mogadouro MA; Mogadouro MA; Mast G; Mast G; Mast G; Moreno CN; Moreno CN; Niquin GDR; Niquin GDR; Barbaresi V; Barbaresi V; Bruhn Cruz A; Bruhn Cruz A; Ferreyro BL; Ferreyro BL; Torres A; Torres A
- Source:
Critical care (London, England) [Crit Care] 2022 Jan 07; Vol. 26 (1), pp. 16. Date of Electronic Publication: 2022 Jan 07.- Publication Type:
Journal Article; Multicenter Study- Language:
English - Source:
- Additional Information
- Corporate Authors:
- Source: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
- Publication Information: Publication: London, UK : BioMed Central Ltd
Original Publication: London : Current Science Ltd, c1997- - Subject Terms:
- Abstract: Background: In patients with COVID-19-related acute respiratory failure (ARF), awake prone positioning (AW-PP) reduces the need for intubation in patients treated with high-flow nasal oxygen (HFNO). However, the effects of different exposure times on clinical outcomes remain unclear. We evaluated the effect of AW-PP on the risk of endotracheal intubation and in-hospital mortality in patients with COVID-19-related ARF treated with HFNO and analyzed the effects of different exposure times to AW-PP.
Methods: This multicenter prospective cohort study in six ICUs of 6 centers in Argentine consecutively included patients > 18 years of age with confirmed COVID-19-related ARF requiring HFNO from June 2020 to January 2021. In the primary analysis, the main exposure was awake prone positioning for at least 6 h/day, compared to non-prone positioning (NON-PP). In the sensitivity analysis, exposure was based on the number of hours receiving AW-PP. Inverse probability weighting-propensity score (IPW-PS) was used to adjust the conditional probability of treatment assignment. The primary outcome was endotracheal intubation (ETI); and the secondary outcome was hospital mortality.
Results: During the study period, 580 patients were screened and 335 were included; 187 (56%) tolerated AW-PP for [median (p25-75)] 12 (9-16) h/day and 148 (44%) served as controls. The IPW-propensity analysis showed standardized differences < 0.1 in all the variables assessed. After adjusting for other confounders, the OR (95% CI) for ETI in the AW-PP group was 0.36 (0.2-0.7), with a progressive reduction in OR as the exposure to AW-PP increased. The adjusted OR (95% CI) for hospital mortality in the AW-PP group ≥ 6 h/day was 0.47 (0.19-1.31). The exposure to prone positioning ≥ 8 h/d resulted in a further reduction in OR [0.37 (0.17-0.8)].
Conclusion: In the study population, AW-PP for ≥ 6 h/day reduced the risk of endotracheal intubation, and exposure ≥ 8 h/d reduced the risk of hospital mortality.
(© 2022. The Author(s).) - References: N Engl J Med. 2013 Jun 6;368(23):2159-68. (PMID: 23688302)
Am J Respir Crit Care Med. 2020 Jun 1;201(11):1319-1320. (PMID: 32281885)
Intensive Care Med. 2002 Apr;28(4):414-8. (PMID: 11967594)
Am J Respir Crit Care Med. 2021 Jan 1;203(1):54-66. (PMID: 33119402)
Chest. 2021 Aug;160(2):454-465. (PMID: 33857475)
Chest. 2020 Jul;158(1S):S21-S28. (PMID: 32658648)
Minerva Anestesiol. 2021 Dec;87(12):1383-1385. (PMID: 34263588)
Eur Respir J. 2021 Feb 17;57(2):. (PMID: 33303538)
Ther Adv Respir Dis. 2021 Jan-Dec;15:17534666211009407. (PMID: 33888007)
Ann Intern Med. 2017 Aug 15;167(4):268-274. (PMID: 28693043)
Intensive Care Med. 2019 May;45(5):563-572. (PMID: 30888444)
Lancet Respir Med. 2021 Apr;9(4):407-418. (PMID: 33460571)
Ann Am Thorac Soc. 2021 Sep 7;:. (PMID: 34491885)
JAMA. 2020 Apr 7;323(13):1239-1242. (PMID: 32091533)
Intensive Care Med. 2014 Mar;40(3):332-41. (PMID: 24435203)
Am J Respir Crit Care Med. 2020 May 15;201(10):1299-1300. (PMID: 32228035)
Lancet. 2020 Feb 22;395(10224):565-574. (PMID: 32007145)
Front Physiol. 2020 Mar 12;11:179. (PMID: 32226390)
Am J Emerg Med. 2021 May;43:88-96. (PMID: 33550104)
Crit Care Med. 2021 Oct 1;49(10):e1001-e1014. (PMID: 33927120)
Am J Respir Crit Care Med. 2017 May 1;195(9):1207-1215. (PMID: 27997805)
Lancet Respir Med. 2021 Dec;9(12):1387-1395. (PMID: 34425070)
Int J Epidemiol. 2016 Dec 1;45(6):1887-1894. (PMID: 28089956)
Intensive Care Med. 2021 Jan;47(1):60-73. (PMID: 33211135)
Am Heart J. 2015 Jul;170(1):36-45, 45.e1-11. (PMID: 26093862)
Am J Respir Crit Care Med. 2019 Jun 1;199(11):1368-1376. (PMID: 30576221)
Multivariate Behav Res. 2011 May;46(3):399-424. (PMID: 21818162)
Stat Med. 2015 Dec 10;34(28):3661-79. (PMID: 26238958)
Eur Radiol. 2020 Dec;30(12):6808-6817. (PMID: 32623505)
Int J Surg. 2014 Dec;12(12):1500-24. (PMID: 25046751)
Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263. (PMID: 28459336)
Intensive Care Med. 2021 May;47(5):538-548. (PMID: 33852032)
N Engl J Med. 2015 Jun 4;372(23):2185-96. (PMID: 25981908)
JAMA. 2020 Jun 9;323(22):2329-2330. (PMID: 32329799)
Eur Respir J. 2005 Mar;25(3):534-44. (PMID: 15738300)
Ann Intensive Care. 2020 May 24;10(1):66. (PMID: 32449068)
Lancet Respir Med. 2020 Sep;8(9):853-862. (PMID: 32735842)
Am J Respir Crit Care Med. 2005 Aug 15;172(4):480-7. (PMID: 15901611) - Contributed Indexing: Investigator: AM Tirado; MC Viñas; JM Pintos; ME Gonzalez; M Mateos; MM Laiz; J Garcia Urrutia; M Ruiz Seifert; E Mastroberti
Keywords: Acute respiratory failure; Awake; COVID-19; Endotracheal intubation; Mortality; Prone position - Accession Number: S88TT14065 (Oxygen)
- Publication Date: Date Created: 20220108 Date Completed: 20220113 Latest Revision: 20220113
- Publication Date: 20231215
- Accession Number: PMC8740872
- Accession Number: 10.1186/s13054-021-03881-2
- Accession Number: 34996496
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