Long non-coding RNAs as emerging regulators of miRNAs and epigenetics in diabetes-related chronic kidney disease.

Publisher: Informa Healthcare Country of Publication: England NLM ID: 9510153 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4160 (Electronic) Linking ISSN: 13813455 NLM ISO Abbreviation: Arch Physiol Biochem Subsets: MEDLINE

Publication: London : Informa Healthcare
Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995-

MicroRNAs*/genetics ; RNA, Long Noncoding*/genetics ; Diabetic Nephropathies*/genetics ; Renal Insufficiency, Chronic*/genetics ; Diabetes Mellitus*/genetics; Humans ; Epigenesis, Genetic

Diabetes is one of the major cause of chronic kidney disease (CKD), including "diabetic nephropathy," and is an increasingly prevalent accelerator of the progression of non-diabetic forms of CKD. The long non-coding RNAs (lncRNAs) have come into the limelight in the past few years as one of the emerging weapons against CKD in diabetes. Available data over the past few years demonstrate the interaction of lncRNAs with miRNAs and epigenetic machinery. Interestingly, the evolving data suggest that lncRNAs play a vital role in diabetes-associated CKD by regulation of epigenetic enzymes such as DNA methyltransferase, histone deacetylases, and histone methyltransferases. LncRNAs are also engaged in the regulation of several miRNAs in diabetic nephropathy. Hence this review will elaborate on the association between lncRNAs and their interaction with epigenetic regulators involved in different aspects and thus the progression of CKD in diabetes.

Keywords: LncRNAs; chronic kidney disease; epigenetics; histone modifications; miRNAs

0 (MicroRNAs)
0 (RNA, Long Noncoding)

Date Created: 20220105 Date Completed: 20240327 Latest Revision: 20240327

20240327

10.1080/13813455.2021.2023580

34986074